Department of Public Health Sciences, University of Virginia, Charlottesville, VA.
Division of Infectious Diseases and International Health, University of Virginia School of Medicine, Charlottesville, VA.
Am J Infect Control. 2020 Oct;48(10):1276-1278. doi: 10.1016/j.ajic.2020.01.008. Epub 2020 Mar 4.
Using an ambidirectional case-control study, we found that the odds of Clostridioides difficile infection (CDI) were 3.38 (P = .01) times higher for patients with multidrug-resistant organism (MDRO) colonization compared to those without. MDRO colonization or infection 1-12 months before CDI testing significantly increased risk of positive CDI diagnosis (odds ratio 4.71, P = .02 and odds ratio = 5.03, P = .05, respectively) independent of antibiotic use, age, and comorbidity status. MDRO colonization and infection are associated with CDI, most significantly if they precede CDI.
采用双向病例对照研究，我们发现与无多重耐药菌定植患者相比，多重耐药菌定植患者艰难梭菌感染（CDI）的几率高 3.38 倍（P=0.01）。CDI 检测前 1-12 个月 MDRO 定植或感染显著增加 CDI 阳性诊断的风险（比值比 4.71，P=0.02 和比值比=5.03，P=0.05），独立于抗生素使用、年龄和合并症状态。MDRO 定植和感染与 CDI 相关，若在 CDI 之前发生，其相关性更为显著。
