Pathology & Laboratory Medicine Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, United States.
Pathology & Laboratory Medicine Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, United States.
Pathol Res Pract. 2020 May;216(5):152916. doi: 10.1016/j.prp.2020.152916. Epub 2020 Mar 2.
Ferrous sulfate is an oral iron supplement commonly used to treat iron deficiency anemia. Upper gastrointestinal (GI) tract mucosal damage with associated tissue iron accumulation can sometimes occur with therapeutic dosages of oral iron-containing medications. A distinct histologic pattern of iron deposition with associated inflammatory and reactive changes caused by mucosal injury from oral iron-containing medications has been most commonly described within gastric biopsies and has been referred to as "iron-pill gastritis". There have only been very rare reports of duodenal mucosa biopsies demonstrating predominantly extracellular crystalline iron deposits with surrounding tissue inflammation and injury analogous to the "iron-pill gastritis" pattern. Here we report a case of "iron pill-induced duodenitis", an uncommon histologic pattern of duodenal iron deposition and mucosal injury seen in a female in her 50 s with clinical findings of a duodenal mass.
硫酸亚铁是一种常用的口服铁补充剂，用于治疗缺铁性贫血。在治疗剂量的口服含铁药物中，有时会出现上消化道（GI）道黏膜损伤伴组织铁沉积。口服含铁药物引起的黏膜损伤导致的铁沉积具有独特的组织学模式，伴有炎症和反应性变化，这种变化在胃活检中最为常见，被称为“铁丸性胃炎”。仅有极少数报告描述了十二指肠黏膜活检显示主要为细胞外结晶铁沉积，伴有周围组织炎症和损伤，类似于“铁丸性胃炎”模式。在这里，我们报告了一例“铁丸诱导的十二指肠炎”，这是一种少见的十二指肠铁沉积和黏膜损伤的组织学模式，发生在一名 50 多岁的女性，其临床表现为十二指肠肿块。
