Department of Neurology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
Department of Neurology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
Ultrasound Med Biol. 2020 Jun;46(6):1359-1364. doi: 10.1016/j.ultrasmedbio.2020.01.012. Epub 2020 Mar 4.
This pilot study was aimed at developing an objective method to diagnose migraine by measuring the difference in vasomotor reactivity between migraineurs and non-migraineurs. Thirty patients diagnosed with migraine without aura and 30 healthy patients were recruited. Vasomotor reactivity of all patients was then assessed by measuring the breath holding index (BHI), hyperventilation index and a novel formula, the migraine vascular index (MVI), of the middle cerebral artery using transcranial Doppler ultrasonography. Migraineurs were found to have significantly lower BHI and MVI values (p < 0.001). Logistic regression analysis revealed that MVI was a significant independent predictor of migraine (p = 0.007). The sensitivity and specificity of MVI in diagnosing migraine with a cutoff value of 1.035 were 86.7% and 86.7%, respectively. In conclusion, MVI measurement is a reliable method for objectively diagnosing migraine. Further research is needed to validate the usage of MVI for migraine diagnosis.
本研究旨在通过测量偏头痛患者与非偏头痛患者之间的血管反应性差异，开发一种客观的偏头痛诊断方法。共招募了 30 名偏头痛不伴先兆患者和 30 名健康患者。然后，通过经颅多普勒超声测量屏气指数（BHI）、过度通气指数和一种新的公式——偏头痛血管指数（MVI）来评估所有患者的血管反应性。结果发现，偏头痛患者的 BHI 和 MVI 值明显较低（p < 0.001）。Logistic 回归分析显示，MVI 是偏头痛的一个显著独立预测因子（p = 0.007）。当 MVI 的截断值为 1.035 时，其诊断偏头痛的敏感性和特异性分别为 86.7%和 86.7%。总之，MVI 测量是一种可靠的客观诊断偏头痛的方法。需要进一步的研究来验证 MVI 在偏头痛诊断中的应用。
