Reproductive Medical Center, No. 924 Hospital of Chinese People's Liberation Army, The 1st Xinqiaoyuan Road, Guilin, Guangxi, 541000, PR China.
Reproductive Medical Center, No. 924 Hospital of Chinese People's Liberation Army, The 1st Xinqiaoyuan Road, Guilin, Guangxi, 541000, PR China.
Eur J Obstet Gynecol Reprod Biol. 2020 Apr;247:219-224. doi: 10.1016/j.ejogrb.2020.02.030. Epub 2020 Feb 26.
The aim of this meta-analysis was to compare the perinatal outcomes between the vitrified-warmed day 5 blastocyst transfer (BT) and the vitrified-warmed day 6 blastocyst transfer (BT).
PubMed, EMBASE and the Cochrane Library were searched for the perinatal outcomes after in vitro fertilisation / intracytoplasmic sperm injection (IVF/ICSI) from inception to October 2018.The perinatal outcomes included birth weight, gestational age, number of males, premature delivery, birth defects, and neonatal deaths. We used a random effect model to analyse the summary risk ratios (RRs) and mean difference (WMD) with 95 % confidence intervals (CIs).
Eight retrospective studies that met the inclusion criteria were included. Compared with vitrified-warmed day 5 BT, vitrified-warmed day 6 BT was associated with increased birth weight (WMD = -80.39; 95 % CI = -151.8 to -8.97; I = 41 %, P = 0.03);There was no significant difference in gestational age (WMD = 0.10; 95 % CI =-0.07-0.27; I = 0%, P = 0.24), number of males (RR 0.93, 95 % CI 0.78-1.10; I = 43 %), premature delivery (RR 0.84, 95 % CI 0.13-5.27; I = 72 %), birth defects (RR 1.48, 95 % CI 0.71-3.11; I = 0%) and neonatal deaths (RR 1.2, 95 % CI 0.25-5.71; I = 0%) between the two groups.
Vitrified-warmed day 6 BT is associated with increased birth weight rather than day 5 BT. There was no difference in gestational age, number of males, premature deliveries, birth defects, and neonatal death, between the two groups. These results concluded that vitrified-warmed day 6 BT has no difference compared with vitrified-warmed day 5 BT in regard to adverse impact on perinatal outcomes.
本荟萃分析旨在比较玻璃化冷冻复苏第 5 天囊胚移植（BT）和玻璃化冷冻复苏第 6 天囊胚移植（BT）的围产结局。
检索从建库至 2018 年 10 月的 PubMed、EMBASE 和 Cochrane Library 中关于体外受精/胞浆内单精子注射（IVF/ICSI）后的围产结局。围产结局包括出生体重、胎龄、男性比例、早产、出生缺陷和新生儿死亡。我们使用随机效应模型分析汇总风险比（RR）和均数差值（WMD）及其 95%置信区间（CI）。
纳入 8 项符合条件的回顾性研究。与玻璃化冷冻复苏第 5 天 BT 相比，玻璃化冷冻复苏第 6 天 BT 与出生体重增加相关（WMD=-80.39；95%CI=-151.8 至-8.97；I=41%，P=0.03）；胎龄无显著差异（WMD=0.10；95%CI=-0.07 至 0.27；I=0%，P=0.24）、男性比例（RR 0.93，95%CI 0.78-1.10；I=43%）、早产（RR 0.84，95%CI 0.13-5.27；I=72%）、出生缺陷（RR 1.48，95%CI 0.71-3.11；I=0%）和新生儿死亡（RR 1.2，95%CI 0.25-5.71；I=0%）两组间无差异。
玻璃化冷冻复苏第 6 天 BT 与出生体重增加相关，而不是第 5 天 BT。两组间胎龄、男性比例、早产、出生缺陷和新生儿死亡无差异。这些结果表明，玻璃化冷冻复苏第 6 天 BT 与第 5 天 BT 相比，对围产结局的不良影响无差异。
