Laureate Institute of Brain Research, 6655 South Yale Ave, Tulsa, OK, 74136, United States.
Laureate Institute of Brain Research, 6655 South Yale Ave, Tulsa, OK, 74136, United States.
Drug Alcohol Depend. 2020 Apr 1;209:107941. doi: 10.1016/j.drugalcdep.2020.107941. Epub 2020 Feb 26.
Drug cue reactivity (DCR) is widely used in experimental settings for both assessment and intervention. There is no validated database of pictorial cues available for methamphetamine and opioids.
360 images in three-groups (methamphetamine, opioid and neutral (control)) matched for their content (objects, hands, faces and actions) were selected in an initial development phase. 28 participants with a history of both methamphetamine and opioid use (37.71 ± 8.11 years old, 12 female) with over six months of abstinence were asked to rate images for craving, valence, arousal, typicality and relatedness.
All drug images were differentiated from neutral images. Drug related images received higher arousal and lower valence ratings compared to neutral images (craving (0-100) for neutral (11.5 ± 21.9), opioid (87.7 ± 18.5) and methamphetamine (88 ± 18), arousal (1-9) for neutral (2.4 ± 1.9), opioid (4.6 ± 2.7) and methamphetamine (4.6 ± 2.6), and valence (1-9) for neutral (4.8 ± 1.3), opioid (4.4 ± 1.9) and methamphetamine (4.4 ± 1.8)). There is no difference between methamphetamine and opioid images in craving, arousal and valence. There is a significant positive relationship between the amount of time that participants spent on drug-related images and the craving they reported for the image. Every 10 points of craving were associated with an increased response time of 383 ms. Three image sets were automatically selected for equivalent fMRI tasks (methamphetamine and opioids) from the database (tasks are available at github).
The methamphetamine and opioid cue database (MOCD) provides a resource of validated images/tasks for future DCR studies. Additionally, researchers can select several sets of unique but equivalent images based-on their psychological/physical characteristics for multiple assessments/interventions.
药物线索反应（DCR）广泛应用于实验环境中的评估和干预。目前还没有经过验证的苯丙胺和阿片类药物图片线索数据库。
在初始开发阶段，选择了三组 360 张图片（苯丙胺、阿片类药物和中性（对照）），内容匹配（物体、手、面部和动作）。28 名有苯丙胺和阿片类药物使用史的参与者（37.71±8.11 岁，12 名女性），已戒毒超过六个月，被要求对图片进行渴望、愉悦度、唤醒度、典型性和相关性评分。
所有药物图片都与中性图片区分开来。与中性图片相比，药物相关图片的唤醒度更高，愉悦度更低（渴望（0-100）为中性（11.5±21.9）、阿片类（87.7±18.5）和苯丙胺（88±18）、唤醒度（1-9）为中性（2.4±1.9）、阿片类（4.6±2.7）和苯丙胺（4.6±2.6），愉悦度（1-9）为中性（4.8±1.3）、阿片类（4.4±1.9）和苯丙胺（4.4±1.8））。苯丙胺和阿片类药物图片在渴望、唤醒度和愉悦度方面没有差异。参与者在药物相关图片上花费的时间与他们对图片的渴望程度呈显著正相关。每增加 10 点渴望，反应时间就会增加 383 毫秒。从数据库中自动选择了三组图片集（苯丙胺和阿片类药物）用于等效 fMRI 任务（任务可在 github 上获取）。
苯丙胺和阿片类药物线索数据库（MOCD）为未来的 DCR 研究提供了经过验证的图片/任务资源。此外，研究人员可以根据自己的心理/生理特征选择几组独特但等效的图片，进行多次评估/干预。
