Pittard W B, Geddes K M, Hollis B W
Department of Pediatrics, Medical University of South Carolina, Charleston 29425.
Bone Miner. 1988 Oct;5(1):69-76. doi: 10.1016/0169-6009(88)90007-4.
To determine how well mineralization correlates in the radius and humerus of neonates, we have measured with photon absorptiometry the bone mineral content (BMC) and bone width (BW) in the humerus and radius of well premature neonates and in the radius alone of well term neonates at birth, 8 and 16 weeks of age. These data allow (1) the correlation of bone mineralization in the humerus and radius at birth and over the first 4 months of life and (2) the correlation between bone mineralization in the radius or humerus at birth and that measured at 8 and 16 weeks in the same bone site. The BMC of the radius was significantly (P less than 0.02) correlated with the BMC of the humerus at birth, 8 and 16 weeks, but the BW of the radius was significantly correlated with the BW of the humerus only at 16 weeks. On the other hand, the BMC of the radius at birth in both term and premature neonates failed to correlate significantly (P = ns) with the BMC of the radius at 8 or 16 weeks. In the humerus, the BMC at birth was significantly (P less than 0.001) correlated with that measured at 8 but not at 16 weeks. These data indicate that the humerus and radius increase in mineral content at a similar rate over the first 4 months of life but that one cannot accurately predict from the BMC at birth what the bone mineral content will be at 8 and 16 weeks of age.
为了确定新生儿桡骨和肱骨的矿化关联程度，我们采用光子吸收法测量了健康早产儿肱骨和桡骨以及足月儿出生时、8周和16周时仅桡骨的骨矿物质含量（BMC）和骨宽度（BW）。这些数据能够（1）得出出生时以及出生后前4个月肱骨和桡骨矿化的相关性，（2）得出出生时桡骨或肱骨的矿化与同一骨部位8周和16周时测量的矿化之间的相关性。桡骨的BMC在出生时、8周和16周时与肱骨的BMC显著相关（P小于0.02），但桡骨的BW仅在16周时与肱骨的BW显著相关。另一方面，足月儿和早产儿出生时桡骨的BMC与8周或16周时桡骨的BMC无显著相关性（P = 无显著性差异）。在肱骨中，出生时的BMC与8周时测量的BMC显著相关（P小于0.001），但与16周时测量的BMC不相关。这些数据表明，在出生后前4个月，肱骨和桡骨的矿物质含量以相似的速率增加，但无法根据出生时的BMC准确预测8周和16周时的骨矿物质含量。
