Shofler David, Hamedani Elnaz, Seun Jonathan, Navarrete Ricardo, Thamby Rohan, Harkless Lawrence
Department of Podiatric Medicine, Surgery, and Biomechanics, Western University College of Podiatric Medicine, 309 E 2nd Street, Pomona, CA 91766, USA.
Department of Podiatric Medicine, Surgery, and Biomechanics, Western University College of Podiatric Medicine, 309 E 2nd Street, Pomona, CA 91766, USA.
Clin Podiatr Med Surg. 2020 Apr;37(2):401-407. doi: 10.1016/j.cpm.2019.12.015.
Onychomycosis is especially common among diabetic patients. The purpose of this study was to investigate the efficacy of 10% efinaconazole solution among diabetic subjects, without restriction by nail plate involvement or glycemic control. Forty subjects were enrolled, with 36 reaching their final 50-week follow-up visit. Mycological cure was attained by 21 subjects (58.33%); 8 subjects (20%) attained either clinical cure (0% clinical involvement) or treatment success (≤10% clinical involvement). Glycemic control did not affect clinical outcome. The medication was well tolerated, with 4 local adverse events and no significant adverse events. The medication may represent a useful option for diabetic patients.
甲癣在糖尿病患者中尤为常见。本研究的目的是调查10%艾氟康唑溶液在糖尿病受试者中的疗效，不受甲板受累情况或血糖控制的限制。招募了40名受试者，其中36名完成了为期50周的最终随访。21名受试者（58.33%）实现了真菌学治愈；8名受试者（20%）实现了临床治愈（临床无受累）或治疗成功（临床受累≤10%）。血糖控制不影响临床结果。该药物耐受性良好，有4例局部不良事件，无严重不良事件。该药物可能是糖尿病患者的一个有用选择。
