Department of Neurosurgery, Mount Sinai Hospital, New York, NY, USA.
Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Neurosurg Clin N Am. 2020 Apr;31(2):191-200. doi: 10.1016/j.nec.2019.11.001. Epub 2020 Jan 24.
The combination of separation surgery and stereotactic body radiotherapy optimizes the treatment of metastatic spine tumors. The integration of SBRT into treatment paradigms produces superb local control rates and consequently has diminished the role of surgery from principle treatment to one of adjuvant therapy. Under this paradigm, hybrid therapy for the treatment of metastatic spine tumors employs separation surgery to decompress the spinal cord and stabilize the spine while creating a safe target for ablative SBRT. Hybrid therapy is well tolerated, allows an early return to systemic therapy, and provides durable, local tumor control compared with more aggressive traditional approaches.
分离手术和立体定向体放射治疗的结合优化了转移性脊柱肿瘤的治疗。SBRT 融入治疗模式产生了极好的局部控制率,从而使手术从主要治疗方法转变为辅助治疗方法。在这种模式下,治疗转移性脊柱肿瘤的混合疗法采用分离手术来解除脊髓压迫并稳定脊柱,同时为消融性 SBRT 创建一个安全的靶区。与更激进的传统方法相比,混合疗法具有良好的耐受性,可早期恢复全身治疗,并提供持久的局部肿瘤控制。