School of Behavioural & Health Sciences, Faculty of Heath Sciences, Australian Catholic University, 1100 Nudgee Rd, Banyo, QLD, 4014, Australia.
School of Behavioural & Health Sciences, Faculty of Heath Sciences, Australian Catholic University, 1100 Nudgee Rd, Banyo, QLD, 4014, Australia.
Complement Ther Med. 2020 Mar;49:102294. doi: 10.1016/j.ctim.2019.102294. Epub 2019 Dec 31.
The aim of this research was to review the literature on Alzheimer's disease (AD) with a focus on polyphenolics as antioxidant therapeutics.
This review included a search of the literature up to and including September 2019 in PubMed and MEDLINE databases using search terms that included: Alzheimer's Disease, Aβ peptide, tau, oxidative stress, redox, oxidation, therapeutic, antioxidant, natural therapy, polyphenol. Any review articles, case studies, research reports and articles in English were identified and subsequently interrogated. Citations within relevant articles were also examined for consideration in this review.
Alzheimer's disease is a neurodegenerative disorder that is clinically characterised by the progressive deterioration of cognitive functions and drastic changes in behaviour and personality. Due to the significant presence of oxidative damage associated with abnormal Aβ accumulation and neurofibrillary tangle deposition in AD patients' brains, antioxidant drug therapy has been investigated as potential AD treatment. In particular, naturally occurring compounds, such as plant polyphenols, have been suggested to have potential neuroprotective effects against AD due to their diverse array of physiological actions, which includes potent antioxidant effects.
The impact of oxidative stress and various mechanisms of pathogenesis in AD pathophysiology was demonstrated along with the therapeutic potential of emergent antioxidant drugs to address such mechanism of oxidation.
本研究旨在综述阿尔茨海默病（AD）的文献，重点关注多酚类物质作为抗氧化治疗剂。
本综述包括在 PubMed 和 MEDLINE 数据库中搜索截至 2019 年 9 月的文献，使用的搜索词包括：阿尔茨海默病、Aβ 肽、tau、氧化应激、氧化还原、氧化、治疗、抗氧化、天然疗法、多酚。确定并随后检查了任何综述文章、案例研究、研究报告和英文文章。还检查了相关文章中的引文，以考虑纳入本综述。
阿尔茨海默病是一种神经退行性疾病，临床上表现为认知功能逐渐恶化，行为和个性发生巨大变化。由于 AD 患者大脑中异常 Aβ 积累和神经纤维缠结沉积与氧化损伤的显著存在，抗氧化药物治疗已被研究为潜在的 AD 治疗方法。特别是，天然存在的化合物，如植物多酚，由于其多种生理作用，包括强大的抗氧化作用，被认为具有对抗 AD 的潜在神经保护作用。
本研究证明了氧化应激和 AD 发病机制中的各种机制在 AD 病理生理学中的作用，以及新兴抗氧化药物治疗这些氧化机制的治疗潜力。
