单侧结状神经节切除大鼠孤束核中胆囊收缩素-8结合的减少。

Reduction of CCK-8 binding in the nucleus of the solitary tract in unilaterally nodosectomized rats.

作者信息

Ladenheim E E, Speth R C, Ritter R C

机构信息

Department of Veterinary and Comparative Anatomy, Washington State University, Pullman 99164.

出版信息

Brain Res. 1988 Nov 22;474(1):125-9. doi: 10.1016/0006-8993(88)90675-0.

DOI:10.1016/0006-8993(88)90675-0

PMID:3214705

Abstract

Cholecystokinin octapeptide (CCK-8) binding sites were examined in the caudal hindbrain of unilaterally nodosectomized and intact rats by in vitro autoradiography with 125I-CCK-8. Unilateral nodosectomy caused a significant reduction in CCK-8 binding in the caudal medial nucleus of the solitary tract (NST) on the side ipsilateral to the nodose ganglionectomy. Examination of other caudal hindbrain regions exhibiting CCK-8 binding did not reveal changes in binding in nodosectomized animals compared to controls. These findings suggest that the CCK receptors in this brain region may be located on terminals of vagal afferent neurons.

摘要

通过使用¹²⁵I-CCK-8进行体外放射自显影，研究了单侧结状神经节切除和完整大鼠尾侧后脑内的胆囊收缩素八肽（CCK-8）结合位点。单侧结状神经节切除导致在结状神经节切除术同侧的孤束尾侧内侧核（NST）中CCK-8结合显著减少。与对照组相比，对其他显示CCK-8结合的尾侧后脑区域的检查未发现结状神经节切除动物的结合有变化。这些发现表明，该脑区的CCK受体可能位于迷走传入神经元的终末上。