Assisted Reproduction Center, Northwest Women's and Children's Hospital Affiliated to Xi'an Jiaotong University, Xi'an, People's Republic of China.
Assisted Reproduction Center, Northwest Women's and Children's Hospital Affiliated to Xi'an Jiaotong University, Xi'an, People's Republic of China.
Fertil Steril. 2020 Apr;113(4):811-817. doi: 10.1016/j.fertnstert.2019.11.023. Epub 2020 Mar 5.
To determine the optimal endometrial preparation protocols of frozen-thawed embryo transfer (FET) in young women with regular menstrual cycles.
Retrospective cohort study.
Public fertility center.
PATIENT(S): Infertile women with regular menstrual cycles undergoing FET.
INTERVENTION(S): Natural cycle (NC) treatment for patients with proven ovulation in previous cycles or who refused medication (n = 308), or hormone treatment (HT) for patients who could not be frequently monitored (n = 1,538).
MAIN OUTCOME MEASURE(S): Live-birth rates.
RESULT(S): The live-birth rates were 61.73% in the NC group and 55.11% in the HT group. The effect size of the endometrial preparation on live-birth rates was evaluated in prespecified and exploratory subgroups in each subgroup, and multivariable logistic regression analysis was used to determine which variables could be independently associated with the live-birth rate. The HT patients had a lower chance of live birth in all subgroups: endometrial thickness on the day of progesterone administration, triple-line endometrial pattern, female age at embryo transfer, fertilization type, and protocol in the fresh cycle. Multivariable analysis showed NC to be associated with an increased likelihood of live birth compared with HT.
CONCLUSION(S): Natural cycle treatment has a higher chance of live birth than HT for endometrial preparation in young women with regular menstrual cycles.
确定有规律月经周期的年轻女性冻融胚胎移植（FET）的最佳子宫内膜准备方案。
回顾性队列研究。
公立生育中心。
有规律月经周期、接受 FET 的不孕女性。
自然周期（NC）治疗，用于此前周期有排卵证实或拒绝药物治疗的患者（n = 308），或激素治疗（HT），用于不能频繁监测的患者（n = 1,538）。
活产率。
NC 组活产率为 61.73%，HT 组为 55.11%。在每个亚组的预设和探索性亚组中评估了子宫内膜准备对活产率的影响大小，并使用多变量逻辑回归分析确定哪些变量可与活产率独立相关。在所有亚组中，HT 患者的活产机会较低：孕激素给药日的子宫内膜厚度、三线型子宫内膜模式、胚胎移植时的女性年龄、受精类型和新鲜周期的方案。多变量分析显示 NC 与 HT 相比，活产率更高。
对于有规律月经周期的年轻女性，NC 用于子宫内膜准备的活产机会高于 HT。
