Department of Dermatology, Royal Free London NHS Foundation Trust, Pond Street, London NW3 2QG, UK.
Centre for Rheumatology, Royal Free Campus, University College London, Rowland Hill Street, London NW3 2PF, UK.
Best Pract Res Clin Rheumatol. 2020 Feb;34(1):101489. doi: 10.1016/j.berh.2020.101489. Epub 2020 Mar 5.
Systemic sclerosis is a severe immune-mediated rheumatic disease by virtue of its clinical impact and mortality. There are a number of other sclerosing skin diseases that should be considered in the differential diagnosis and these are important because they may require specialist investigation and management. In addition, long-term follow up of the different conditions should reflect the risk of associated complications and anticipated duration of therapy. This article reviews the clinical features of potential mimics of scleroderma (systemic sclerosis) including localised forms of scleroderma (morphoea) and other conditions that lead to skin thickening and connective tissue fibrosis or scarring.
系统性硬化症是一种严重的免疫介导性风湿病，其临床表现和死亡率均较高。在鉴别诊断中还需要考虑其他一些硬化性皮肤病，这一点很重要，因为这些疾病可能需要专门的检查和治疗。此外，不同疾病的长期随访应反映出相关并发症的风险和预期的治疗持续时间。本文回顾了硬皮病（系统性硬化症）的潜在类似疾病（包括局限性硬皮病[硬斑病]和其他导致皮肤增厚、结缔组织纤维化或瘢痕形成的疾病）的临床特征。
