白细胞介素 22 多态性与感染疟疾的患者。
Interleukin-22 Polymorphisms in -Infected Malaria Patients.
机构信息
Biology Department, College of Science, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.
Department of Infection and Immunity, Research Centre, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia.
出版信息
Mediators Inflamm. 2020 Feb 19;2020:5193723. doi: 10.1155/2020/5193723. eCollection 2020.
UNLABELLED
. Malaria infection, caused by , is the most lethal and frequently culminates in severe clinical complications. Interleukin-22 (IL-22) has been implicated in several diseases including malaria. The objective of this study was to investigate the role of IL-22 gene polymorphisms in . infection. . Ten single-nucleotide polymorphisms (SNPs), rs976748, rs1179246, rs2046068, rs1182844, rs2227508, rs2227513, rs2227478, rs2227481, rs2227491, and rs2227483, of gene were genotyped through PCR-based assays of 250 . infection. - gene promoter activity.
RESULTS
We found that the rs2227481 TT genotype (odds ratio 0.254, confidence interval = 0.097-0.663, . . infection. . . . .
CONCLUSION
The study suggests that IL-22 polymorphisms in rs2227481 and rs2227483 could contribute to protection against . infection. - gene promoter activity.
未标记
由引起的疟疾感染是最致命的，经常导致严重的临床并发症。白细胞介素-22（IL-22）已被涉及多种疾病，包括疟疾。本研究的目的是研究 IL-22 基因多态性在感染中的作用。十个单核苷酸多态性（SNP），rs976748、rs1179246、rs2046068、rs1182844、rs2227508、rs2227513、rs2227478、rs2227481、rs2227491 和 rs2227483，通过 PCR 基于 250 名感染的基因分型检测。-基因启动子活性。
结果
我们发现 rs2227481 TT 基因型（比值比 0.254，置信区间 0.097-0.663，）与感染风险降低相关。此外，rs2227481 TT 基因型与更高的-基因启动子活性相关。
结论
研究表明，rs2227481 和 rs2227483 中的 IL-22 多态性可能有助于预防感染。-基因启动子活性。
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