使用缓释注射用阿立哌唑成功治疗双相I型障碍的抑郁症状
Using Extended-Release Injectable Aripiprazole for the Successful Treatment of Depressive Symptoms in Bipolar I Disorder.
作者信息
Kuo Joseph, Lin Shih-Ku
机构信息
Department of Psychiatry, Camillians Saint Mary's Hospital Luodong, Yilan, Taiwan.
Taipei City Hospital and Psychiatric Center, Taipei, Taiwan.
出版信息
Case Rep Psychiatry. 2020 Feb 21;2020:2615748. doi: 10.1155/2020/2615748. eCollection 2020.
Abstract
Extended-release injectable (ERI) aripiprazole is indicated for schizophrenia and maintenance monotherapy of bipolar I disorder. Clinical trials of aripiprazole failed to exhibit efficacy in the treatment of bipolar depression. It has been suggested that relatively high doses, rapid titration of dose, a high dropout rate, and a high placebo effect might be the reasons of its ineffectiveness. Here, we report a case of a 39-year-old woman with bipolar depression who was successfully treated with ERI aripiprazole.
摘要
长效注射用阿立哌唑适用于精神分裂症及双相I型障碍的维持单药治疗。阿立哌唑的临床试验未能显示出其在双相抑郁治疗中的疗效。有人认为，相对高的剂量、快速的剂量滴定、高脱落率和高安慰剂效应可能是其无效的原因。在此，我们报告一例39岁双相抑郁女性患者，其接受长效注射用阿立哌唑治疗取得成功。
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本文引用的文献
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The Utility of Low-Dose Aripiprazole for the Treatment of Bipolar II and Bipolar NOS Depression.低剂量阿立哌唑治疗双相II型障碍及未特定的双相障碍抑郁发作的效用
J Clin Psychopharmacol. 2017 Feb;37(1):99-101. doi: 10.1097/JCP.0000000000000636.
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A clinical review of aripiprazole in bipolar depression and maintenance therapy of bipolar disorder.阿立哌唑治疗双相抑郁的临床评价及双相障碍的维持治疗。
J Affect Disord. 2011 Jan;128 Suppl 1:S21-8. doi: 10.1016/S0165-0327(11)70005-2.
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Aripiprazole as adjunct to a mood stabilizer and citalopram in bipolar depression: a randomized placebo-controlled pilot study.阿立哌唑作为心境稳定剂和西酞普兰治疗双相抑郁的辅助用药：一项随机安慰剂对照的初步研究。
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Aripiprazole monotherapy in nonpsychotic bipolar I depression: results of 2 randomized, placebo-controlled studies.阿立哌唑单药治疗非精神病性双相I型抑郁症：两项随机、安慰剂对照研究的结果
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