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复杂肝癌手术切除的有效性及其影响因素:一项回顾性研究。

Effectiveness of surgical resection for complicated liver cancer and its influencing factors: A retrospective study.

作者信息

Yu Jian, Wu Zhi-Zheng, Li Teng, Xu Ying, Zhao Yu-Cheng, Zhang Bo-Lun, Tian Hu

机构信息

Department of General Surgery, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan 250014, Shandong Province, China.

Department of Hepatological Surgery, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan 250014, Shandong Province, China.

出版信息

World J Clin Cases. 2020 Feb 26;8(4):736-742. doi: 10.12998/wjcc.v8.i4.736.

Abstract

BACKGROUND

Surgical resection is the preferred method for patients with complex liver cancer. But the tumor is in a special position, the surgery is highly risky, postoperative complications can easily occur, and the prognosis is not ideal.

AIM

To investigate the effectiveness of surgical resection for complex liver cancer and its influencing factors.

METHODS

Fifty-seven patients who had complicated liver cancer and underwent surgical resection at our hospital from August 2015 to August 2016 were enrolled in this study. All patients were followed for three years, and their postoperative complications, survival, and factors that impacted their survival were analyzed.

RESULTS

The total incidence of postoperative complications was 45.61%, and the incidence of pleural effusion was the highest at 28.07%. There were no correlations between the 2-year and 3-year survival rates and sex, age, and HbsAg of the patients ( > 0.05). In terms of pathological parameters, the 2-year and 3-year survival rates were significantly different according to the presence of a tumor capsule, degree of liver cirrhosis, satellite or focal lesions, hepatic vein thrombosis, portal vein tumor thrombus, and intraoperative blood loss ( < 0.05).

CONCLUSION

The effectiveness of surgical resection for complex hepatocellular carcinoma may be affected by factors such as the presence of a tumor capsule, cirrhosis degree, satellite or focal lesions, hepatic vein embolization, portal vein tumor thrombus, and intraoperative blood loss. Therefore, these factors should be controlled and prevented during surgery to help improve patient survival after surgery.

摘要

背景

手术切除是复杂肝癌患者的首选治疗方法。但肿瘤位置特殊,手术风险高,术后易发生并发症,预后不理想。

目的

探讨复杂肝癌手术切除的疗效及其影响因素。

方法

选取2015年8月至2016年8月在我院接受手术切除的57例复杂肝癌患者作为研究对象。对所有患者进行三年随访,分析其术后并发症、生存情况及影响生存的因素。

结果

术后并发症总发生率为45.61%,其中胸腔积液发生率最高,为28.07%。患者的2年和3年生存率与性别、年龄、乙肝表面抗原(HbsAg)无关(P>0.05)。在病理参数方面,根据肿瘤包膜的有无、肝硬化程度、卫星灶或局灶性病变、肝静脉血栓形成、门静脉癌栓及术中失血量,2年和3年生存率有显著差异(P<0.05)。

结论

复杂肝细胞癌手术切除的疗效可能受肿瘤包膜的有无、肝硬化程度、卫星灶或局灶性病变、肝静脉栓塞、门静脉癌栓及术中失血量等因素影响。因此,手术中应控制和预防这些因素,以提高患者术后生存率。

相似文献

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1
Challenges in liver cancer and possible treatment approaches.肝癌的挑战与可能的治疗方法。
Biochim Biophys Acta Rev Cancer. 2020 Jan;1873(1):188314. doi: 10.1016/j.bbcan.2019.188314. Epub 2019 Nov 1.
10
Liver Cancer Treatment Approved.肝癌治疗获批准。
JAMA. 2017 Jun 6;317(21):2157. doi: 10.1001/jama.2017.6339.

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