运动对糖尿病黎明现象患者血糖及血糖变异性的影响。
Effects of Exercise on Blood Glucose and Glycemic Variability in Type 2 Diabetic Patients with Dawn Phenomenon.
机构信息
Department of Endocrinology, China Rehabilitation Research Center, Beijing 100068, China.
Department of Clinical Nutrition, China Rehabilitation Research Center, Beijing 100068, China.
出版信息
Biomed Res Int. 2020 Feb 21;2020:6408724. doi: 10.1155/2020/6408724. eCollection 2020.
BACKGROUND
The dawn phenomenon (DP) is the primary cause of difficulty in blood glucose management in type 2 diabetic (T2D) patients, and the use of oral hypoglycemic agents has shown weak efficacy in controlling DP. Thus, this study is aimed at investigating the effect of moderate-intensity aerobic exercise before breakfast on the blood glucose level and glycemic variability in T2D patients with DP.
METHODS
A total of 20 T2D patients with DP confirmed via continuous glucose monitoring (CGM) participated in the current study. After collecting baseline measurements by CGM as a control, CGM was reinstalled and 30 minutes of moderate-intensity aerobic exercise was performed prior to breakfast. Dawn blood glucose increase, blood glucose levels, and glycemic variability were measured before and after exercise.
RESULTS
Dawn blood glucose increase (Glu, 1.25 ± 0.842.15 ± 1.07, = 0.005), highest blood glucose value before breakfast (Gmax, 8.01 ± 1.16. 8.78 ± 1.09, = 0.005), highest blood glucose value before breakfast (Gmax, 8.01 ± 1.16. 8.78 ± 1.09, = 0.005), highest blood glucose value before breakfast (Gmax, 8.01 ± 1.16. 8.78 ± 1.09, = 0.005), highest blood glucose value before breakfast (Gmax, 8.01 ± 1.16. 8.78 ± 1.09, = 0.005), highest blood glucose value before breakfast (Gmax, 8.01 ± 1.162.15 ± 1.07, = 0.005), highest blood glucose value before breakfast (Gmax, 8.01 ± 1.162.15 ± 1.07, = 0.005), highest blood glucose value before breakfast (Gmax, 8.01 ± 1.162.15 ± 1.07, = 0.005), highest blood glucose value before breakfast (Gmax, 8.01 ± 1.16.
CONCLUSIONS
Acute moderate-intensity aerobic exercise before breakfast reduced the morning rise of blood glucose in T2D patients, partially counteracting DP. Furthermore, exercise significantly reduced blood glucose fluctuations and improved blood glucose control throughout the day. We recommend that T2D patients with DP take moderate-intensity aerobic exercise before breakfast to improve DP and glycemic control.
背景
黎明现象（DP）是 2 型糖尿病（T2D）患者血糖管理困难的主要原因，口服降糖药在控制 DP 方面效果较弱。因此，本研究旨在探讨早餐前进行中等强度有氧运动对 DP 的 T2D 患者血糖水平和血糖变异性的影响。
方法
通过连续血糖监测（CGM）共纳入 20 例 DP 确诊的 T2D 患者。在 CGM 收集基线测量值作为对照后，重新安装 CGM 并在早餐前进行 30 分钟的中等强度有氧运动。测量运动前后黎明时血糖升高、血糖水平和血糖变异性。
结果
黎明时血糖升高（Glu，1.25±0.84 vs. 2.15±1.07， = 0.005）、早餐前最高血糖值（Gmax，8.01±1.16 vs. 8.78±1.09， = 0.005）、早餐前最高血糖值（Gmax，8.01±1.16 vs. 8.78±1.09， = 0.005）、早餐前最高血糖值（Gmax，8.01±1.16 vs. 8.78±1.09， = 0.005）、早餐前最高血糖值（Gmax，8.01±1.16 vs. 8.78±1.09， = 0.005）、早餐前最高血糖值（Gmax，8.01±1.16 vs. 8.78±1.09， = 0.005）、早餐前最高血糖值（Gmax，8.01±1.16 vs. 8.78±1.09， = 0.005）、早餐前最高血糖值（Gmax，8.01±1.16 vs. 8.78±1.09， = 0.005）、早餐前最高血糖值（Gmax，8.01±1.16 vs. 8.78±1.09， = 0.005）。
结论
早餐前进行急性中等强度有氧运动可降低 T2D 患者清晨血糖升高，部分抵消 DP 的影响。此外，运动显著降低了全天的血糖波动，改善了血糖控制。我们建议 DP 的 T2D 患者在早餐前进行中等强度的有氧运动，以改善 DP 和血糖控制。
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