3rd Department of Internal Medicine, Laboratory for Endocrinology and Metabolism, 1st Faculty of Medicine, Charles University and General Faculty Hospital, U Nemocnice 1, 12808, Prague 2, Czech Republic.
Rev Endocr Metab Disord. 2016 Mar;17(1):103-10. doi: 10.1007/s11154-016-9347-2.
Microvascular complications in diabetes are associated with poor long-term diabetes control as measured by HbA1c levels. Glucose fluctuations are related to oxidative stress, endothelial dysfunction, and inflammation, factors traditionally associated with the pathogenesis of vascular damage. Glucose variability has been associated with macrovascular disease in some studies but any association with microvascular disease remains controversial. This overview summarizes recent findings in the field of glucose variability and its possible relationship with retinopathy, nephropathy and neuropathy. It is concluded that randomized prospective follow-up trials could possibly help estimate whether short-term glucose variability should be considered as an independent risk factor for microvascular complications in diabetes.
糖尿病的微血管并发症与 HbA1c 水平所反映的长期血糖控制不良有关。血糖波动与氧化应激、内皮功能障碍和炎症有关，这些因素通常与血管损伤的发病机制有关。一些研究表明，血糖波动与大血管疾病有关，但与微血管疾病的任何关联仍存在争议。这篇综述总结了血糖波动领域的最新发现及其与视网膜病变、肾病和神经病变的可能关系。结论是，随机前瞻性随访试验可能有助于评估短期血糖波动是否应被视为糖尿病微血管并发症的独立危险因素。
