Departamento de Pediatria, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP 05403-000, Brazil.
Departamento de Clinica Cirúrgica, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP 01246-903, Brazil.
Medicina (Kaunas). 2020 Mar 5;56(3):116. doi: 10.3390/medicina56030116.
Background and Objectives: Cirrhosis is a liver disease that causes about one million deaths annually worldwide. The estimated cirrhosis prevalence ranges from 4.5-9.5% in the general population. Up to 40% of cirrhotic patients are asymptomatic and may be diagnosed late. Studies have described the importance of the functions of the liver and autonomic nervous system (ANS) and their relationship. There is limited information available on non-alcoholic cirrhosis and heart rate variability (HRV), which is a measure of the ANS. This study aimed to evaluate cardiac autonomic modulation through HRV in non-alcoholic cirrhosis individuals reported in previous observational and clinical trial studies. We performed a systematic review according to the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) statement using the Medline, Scopus, and Web of Science electronic databases. Five studies were identified and reviewed. HRV was decreased in patients with non-alcoholic cirrhosis, even in the first stage. HRV could be used as a complementary method to improve both the diagnosis and prognosis of non-alcoholic cirrhosis.
肝硬化是一种肝脏疾病，每年在全球导致约 100 万人死亡。在一般人群中，肝硬化的估计患病率范围为 4.5-9.5%。多达 40%的肝硬化患者无症状，可能被诊断较晚。研究已经描述了肝脏和自主神经系统（ANS）及其关系的功能的重要性。关于非酒精性肝硬化和心率变异性（HRV）的信息有限，HRV 是 ANS 的一种测量方法。本研究旨在通过 HRV 评估先前观察性和临床试验研究中报告的非酒精性肝硬化个体的心脏自主神经调节。我们根据系统评价和荟萃分析的首选报告项目（PRISMA）声明，使用 Medline、Scopus 和 Web of Science 电子数据库进行了系统评价。确定并审查了五项研究。非酒精性肝硬化患者的 HRV 降低，即使在第一阶段也是如此。HRV 可以用作一种补充方法，以改善非酒精性肝硬化的诊断和预后。
