自噬对肝脏疾病的影响。

Effect of Autophagy Over Liver Diseases.

作者信息

Yi Dong-Qian, Yang Xue-Feng, Liao Duan-Fang, Wu Qing, Fu Nian, Hu Yang, Cao Ting

机构信息

Department of Digestion Internal Medicine, the Affiliated Nanhua Hospital of University of South China, Hengyang 421000, Hunan, China.

Department of Pathology, Hunan University of Chinese Medicine, Changsha 410208, China.

出版信息

Chin Med Sci J. 2016 Mar 20;31(1):65-68. doi: 10.1016/s1001-9294(16)30026-8.

DOI:10.1016/s1001-9294(16)30026-8

PMID:28031092

Abstract

In recent years, increasingly evidences show that autophagy plays an important role in the pathogenesis and development of liver diseases, and the relationship between them has increasingly become a focus of concern. Autophagy refers to the process through which the impaired organelles, misfolded protein, and intruding microorganisms is degraded by lysosomes to maintain stability inside cells. This article states the effect of autophagy on liver diseases (hepatic fibrosis, fatty liver, viral hepatitis, and liver cancer), which aims to provide a new direction for the treatment of liver diseases.

摘要

近年来，越来越多的证据表明自噬在肝脏疾病的发病机制和发展过程中发挥着重要作用，二者之间的关系也日益成为人们关注的焦点。自噬是指受损细胞器、错误折叠的蛋白质和入侵微生物被溶酶体降解以维持细胞内稳定性的过程。本文阐述了自噬对肝脏疾病（肝纤维化、脂肪肝、病毒性肝炎和肝癌）的影响，旨在为肝脏疾病的治疗提供新的方向。