Rose S R, Klein-Schwartz W, Oderda G M, Gorman R L, Young W W
Clinical Toxicology Services, University Hospital, Jacksonville, FL 32209.
Drug Intell Clin Pharm. 1988 Sep;22(9):691-4. doi: 10.1177/106002808802200908.
A 65-year-old female presented with only gastrointestinal symptoms eight to ten hours after an acute ingestion of an unknown amount of lithium carbonate. The serum lithium concentration was 8.5 mEq/L. Forty-eight hours postingestion she developed acute renal failure, deteriorating mental status, and cardiovascular collapse. Despite both hemodialysis and peritoneal dialysis the patient died approximately four and one-half days after ingestion. A direct nephrotoxic effect of lithium is proposed.
一名65岁女性在急性摄入未知量碳酸锂8至10小时后仅出现胃肠道症状。血清锂浓度为8.5 mEq/L。摄入后48小时，她出现急性肾衰竭、精神状态恶化和心血管衰竭。尽管进行了血液透析和腹膜透析，患者在摄入后约四天半死亡。有人提出锂具有直接肾毒性作用。
