从飞龙掌血中分离得到的四个新化学成分。
Four new chemical constituents from Piper pleiocarpum.
机构信息
Key Laboratory for Forest Resources Conservation and Utilization in the Southwest Mountains of China, Ministry of Education, Southwest Forestry University, Kunming 650224, PR China.
Key Laboratory of Forest Disaster Warning and Control of Yunnan Province, Southwest Forestry University, Kunming 650224, PR China.
出版信息
Fitoterapia. 2020 Jun;143:104544. doi: 10.1016/j.fitote.2020.104544. Epub 2020 Mar 6.
Two new polyoxygenated cyclohexenes (1-2), one new benzoate derivative (3), and one new dineolignan (4) together with one known neolignan (5) were isolated from whole plants of Piper pleiocarpum. The structures of these compounds were determined by extensive spectroscopic methods including 1D, 2D NMR, HR-ESI-MS, and by comparison with the literature. The C NMR spectra of the known compound 5 were completely assigned for the first time. All isolated compounds (1-5) were evaluated for their cytotoxic activities against five human cancer cell lines (including A-549, SMMC-7721, HL-60, MCF-7, and SW-480), Only compound 4 showed inhibitory activity against MCF-7 cell line with IC value of 18.24 ± 0.69 μM.
从棱子芹 Piper pleiocarpum 的全株植物中分离得到了两个新的多氧化环己烯（1-2）、一个新的苯甲酸酯衍生物（3）和一个新的二木脂素（4）以及一个已知的新木脂素（5）。通过广泛的光谱方法，包括 1D、2D NMR、HR-ESI-MS 以及与文献的比较，确定了这些化合物的结构。首次对已知化合物 5 的 13C NMR 谱进行了完全归属。对所有分离得到的化合物（1-5）进行了对五种人癌细胞系（包括 A-549、SMMC-7721、HL-60、MCF-7 和 SW-480）的细胞毒性活性评价，只有化合物 4 对 MCF-7 细胞系表现出抑制活性，IC 值为 18.24±0.69μM。
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