锂可改变大鼠皮层中肌醇磷脂的代谢，而卡马西平则无此作用。

Alteration of inositol phospholipid metabolism in rat cortex by lithium but not carbamazepine.

作者信息

Elphick M, Taghavi Z, Powell T, Godfrey P P

机构信息

Department of Clinical Pharmacology, Radcliffe Infirmary, Oxford, U.K.

出版信息

Eur J Pharmacol. 1988 Nov 8;156(3):411-4. doi: 10.1016/0014-2999(88)90287-7.

DOI:10.1016/0014-2999(88)90287-7

PMID:3215284

Abstract

The effect of carbamazepine on inositol phospholipid metabolism was investigated in rat cerebral cortex. The stimulation of inositol phosphate formation by 5-HT (10 microM), carbachol (100 microM) and noradrenaline (30 microM) was not significantly altered by carbamazepine in vitro. 14 days treatment of rats in vivo with carbamazepine was similarly without effect on these parameters. In contrast 14 days treatment with LiCl reduced the agonist responses by 25-50%. The results are discussed in relation to the therapeutic actions of these drugs.

摘要

在大鼠大脑皮层中研究了卡马西平对肌醇磷脂代谢的影响。在体外，卡马西平对5-羟色胺（10微摩尔）、氨甲酰胆碱（100微摩尔）和去甲肾上腺素（30微摩尔）刺激的肌醇磷酸形成无显著改变。在体内用卡马西平对大鼠进行14天治疗，对这些参数同样无影响。相比之下，用氯化锂治疗14天使激动剂反应降低了25%-50%。结合这些药物的治疗作用对结果进行了讨论。