Tsinghua-Peking Joint Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Medicine, Tsinghua University, Beijing, 100084, China.
Institute of Pathogenic Organisms, Shenzhen Center for Disease Control and Prevention, Shenzhen, 518055, Guangdong, China.
Adv Exp Med Biol. 2020;1204:129-140. doi: 10.1007/978-981-15-1580-4_5.
C-type lectins (CTLs) are a family of carbohydrate-recognition domain (CRD)-containing proteins that bind to ligands in a calcium-dependent manner. CTLs act as important components of insect innate immune responses, such as pattern recognition, agglutination, encapsulation, melanization, phagocytosis and prophenoloxidase activation, as well as gut microbiome homeostasis maintenance, to defend against pathogens. Besides, some insect CTLs can facilitate pathogen infection and colonization. In this review, we describe the properties of insect CTLs and focus on explaining their role in viral, bacterial, parasitic and fungal infections.
C 型凝集素（CTLs）是一类含有碳水化合物识别结构域（CRD）的蛋白质，它们以依赖于钙离子的方式与配体结合。CTLs 作为昆虫先天免疫反应的重要组成部分，参与模式识别、凝集、包裹、黑化、吞噬和酚氧化酶原激活以及肠道微生物组稳态维持等过程，以抵御病原体。此外，一些昆虫 CTLs 可以促进病原体的感染和定植。在本文中，我们描述了昆虫 CTLs 的特性，并重点解释了它们在病毒、细菌、寄生虫和真菌感染中的作用。
