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急性 A 型主动脉夹层采用脊髓保护灌注策略行冰冻象鼻手术的早期和中期结果。

Early and mid-term outcome of frozen elephant trunk using spinal cord protective perfusion strategy for acute type A aortic dissection.

机构信息

Department of Cardiovascular Surgery, Japanese Red Cross Kyoto Daini Hospital, 355-5 Haruobi-cho, Kamigyo-ku, Kyoto, 602-8026, Japan.

出版信息

Gen Thorac Cardiovasc Surg. 2020 Oct;68(10):1119-1127. doi: 10.1007/s11748-020-01328-z. Epub 2020 Mar 9.

Abstract

OBJECTIVE

This study aimed to evaluate the prevalence of spinal cord injury in total arch replacement with frozen elephant trunk for acute type A aortic dissection using our spinal cord protection technique.

METHODS

Between January 2013 and December 2017, 33 patients underwent total arch replacement with frozen elephant trunk for acute type A aortic dissection (mean age 67.9 ± 13.3 years). Our spinal cord protection technique involved maintaining extracorporeal circulation through the left subclavian artery in all procedures, using aortic occlusion balloon during distal anastomosis, and inserting frozen elephant trunk above Th 8 with transesophageal echocardiographic guidance. Computed tomography was performed within 1-2 weeks, 12 months, and 36 months postoperatively. We compared the degree of thrombosis of the descending aorta between preoperation and early postoperative period by Fisher's exact test. Moreover, we evaluated postoperative mortality and mobility (including spinal cord injury) at follow-up.

RESULTS

The operative mortality within 30 days was 6.1%. Neither paraplegia nor paraparesis was noted. We observed significant thrombosis of the false lumen at the distal arch and aortic valve level of the descending aorta in postoperative early term period (p < 0.01). At mid-term follow-up (mean 33.9 months), survival probability and 3-year freedom from reoperation rates were 93.9 ± 4.1% and 95.0 ± 4.9%, respectively.

CONCLUSIONS

The frozen elephant trunk technique with our spinal protection strategy provides good postoperative outcomes. Our strategy can maintain spinal cord perfusion without complete ischemia time even during lower body ischemia time. Implementation of our spinal protection strategy will help prevent spinal cord injury and dilated downstream aorta.

摘要

目的

本研究旨在评估应用我们脊髓保护技术的全主动脉弓置换加冷冻象鼻手术治疗急性 A 型主动脉夹层的脊髓损伤发生率。

方法

2013 年 1 月至 2017 年 12 月,33 例急性 A 型主动脉夹层患者接受全主动脉弓置换加冷冻象鼻手术(平均年龄 67.9±13.3 岁)。我们的脊髓保护技术包括在所有手术中通过左锁骨下动脉维持体外循环,在远端吻合时使用主动脉阻断球囊,并在经食管超声心动图引导下将冷冻象鼻插入 Th8 以上。术后 1-2 周、12 个月和 36 个月行 CT 检查。我们通过 Fisher 确切检验比较术前和术后早期降主动脉血栓形成的程度。此外,我们还评估了术后随访时的死亡率和活动能力(包括脊髓损伤)。

结果

术后 30 天内死亡率为 6.1%。无截瘫或不全截瘫发生。我们观察到术后早期降主动脉远端弓和主动脉瓣水平的假腔有明显血栓形成(p<0.01)。中期随访(平均 33.9 个月),生存率和 3 年免于再次手术率分别为 93.9±4.1%和 95.0±4.9%。

结论

应用我们脊髓保护策略的冷冻象鼻技术可获得良好的术后结果。我们的策略可以在下肢缺血时间内保持脊髓灌注,而无需完全缺血时间。实施我们的脊髓保护策略有助于预防脊髓损伤和扩张下游主动脉。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc7e/7522075/26ec646c8b77/11748_2020_1328_Fig1_HTML.jpg

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