利用昆虫作为生物模型评估纳米颗粒的毒性。

Assessment of Toxicity of Nanoparticles Using Insects as Biological Models.

机构信息

Materials Science and Mechanical Engineering, Texas A&M University, College Station, TX, USA.

出版信息

Methods Mol Biol. 2020;2118:269-279. doi: 10.1007/978-1-0716-0319-2_20.

Abstract

Nanomaterials have become increasingly important in medicine, manufacturing, and consumer products. A fundamental understanding of the effects of nanoparticles (NPs) and their interactions with biomolecules and organismal systems has yet to be achieved. In this chapter, we firstly provide a brief review of the interactions between nanoparticles and biological systems. We then provide an example by describing a novel method to assess the effects of NPs on biological systems, using insects as a model. Nanoparticles were injected into the central nervous system of the discoid cockroach (Blaberus discoidalis). It was found that insects became hyperactive compared to negative control (water injections). Our method could provide a generic method of assessing nanoparticles toxicity.

摘要

纳米材料在医学、制造和消费产品领域变得越来越重要。然而，人们对于纳米颗粒（NPs）的作用及其与生物分子和机体系统的相互作用还没有一个基本的了解。在这一章中，我们首先简要回顾了纳米颗粒与生物系统之间的相互作用。然后，我们通过描述一种评估 NPs 对生物系统影响的新方法，以昆虫为模型，提供了一个示例。将纳米颗粒注入圆盘状蟑螂（Blaberus discoidalis）的中枢神经系统。与阴性对照（水注射）相比，发现昆虫变得更加活跃。我们的方法可以为评估纳米颗粒毒性提供一种通用的方法。