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J Ophthalmol. 2017;2017:2646904. doi: 10.1155/2017/2646904. Epub 2017 Jul 2.
2
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3
Effect of the Rho-Associated Kinase Inhibitor Eye Drop (Ripasudil) on Corneal Endothelial Wound Healing.Rho相关激酶抑制剂滴眼液（丽科明）对角膜内皮伤口愈合的影响。
Invest Ophthalmol Vis Sci. 2016 Mar;57(3):1284-92. doi: 10.1167/iovs.15-18586.
4
Effect of fluidics on corneal endothelial cell density, central corneal thickness, and central macular thickness after phacoemulsification with torsional ultrasound.扭转超声乳化术后流体力学对角膜内皮细胞密度、中央角膜厚度和中央黄斑厚度的影响。
Indian J Ophthalmol. 2015 Aug;63(8):641-4. doi: 10.4103/0301-4738.169786.
5
The effects of Rho-associated kinase inhibitor Y-27632 on primary human corneal endothelial cells propagated using a dual media approach.Rho相关激酶抑制剂Y-27632对采用双培养基法培养的原代人角膜内皮细胞的影响。
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6
Intra-ocular pressure-lowering effects of a Rho kinase inhibitor, ripasudil (K-115), over 24 hours in primary open-angle glaucoma and ocular hypertension: a randomized, open-label, crossover study.Rho激酶抑制剂法舒地尔（K-115）对原发性开角型青光眼和高眼压症患者24小时眼压降低作用的随机、开放标签、交叉研究
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Ripasudil: first global approval.利匹司他：全球首次批准。
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Preliminary study of the association between corneal histocytological changes and surgically induced astigmatism after phacoemulsification.白内障超声乳化术后角膜组织细胞学变化与手术性散光相关性的初步研究
BMC Ophthalmol. 2014 Nov 20;14:134. doi: 10.1186/1471-2415-14-134.
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Rho激酶抑制剂的围手术期使用对白内障超声乳化术后角膜内皮有有益作用。

Perioperative Use of Rho-Kinase Inhibitors has Beneficial Effect on Corneal Endothelium after Phacoemulsification.

作者信息

Alkharashi Majed, AlAbbasi Omar, Magliyah Moustafa

机构信息

Department of Ophthalmology, King Saud University, Riyadh, Saudi Arabia.

Cornea and Anterior Segment Consultant, King Abdulaziz University Hospital, Riyadh, Saudi Arabia.

出版信息

Middle East Afr J Ophthalmol. 2020 Jan 29;26(4):246-249. doi: 10.4103/meajo.MEAJO_27_19. eCollection 2019 Oct-Dec.

DOI:10.4103/meajo.MEAJO_27_19
PMID:32153339
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7034144/
Abstract

PURPOSE

Does perioperative use of Rho-Kinase (ROCK) inhibitors have beneficial effect on corneal endothelial cells after phacoemulsification? SETTING: This study was conducted at King Abdulaziz University Hospital in Riyadh.

DESIGN

This was a prospective study assessing the effect of ROCK inhibitors on corneal endothelium after phacoemulsification.

METHODOLOGY

Three patients have used ROCK inhibitor 1 day before and 1 week after phacoemulsification surgery, and specular microscopy and Pentacam were done preoperatively and 3 months postoperatively.

RESULTS

Endothelial cell density decreased to 11.3%, 9.45%, and 4.09% in eyes with ROCK inhibitors and 23.9% in one eye without ROCK inhibitor.

CONCLUSION

Perioperative ROCK inhibitor use has a possible protective effect on corneal endothelium.

摘要

目的

围手术期使用Rho激酶（ROCK）抑制剂对白内障超声乳化术后角膜内皮细胞是否有有益作用？

设置

本研究在利雅得的阿卜杜勒阿齐兹国王大学医院进行。

设计

这是一项前瞻性研究，评估ROCK抑制剂对白内障超声乳化术后角膜内皮的影响。

方法

3例患者在白内障超声乳化手术前1天和术后1周使用ROCK抑制剂，术前和术后3个月进行角膜内皮镜检查和Pentacam检查。

结果

使用ROCK抑制剂的眼中内皮细胞密度分别下降至11.3%、9.45%和4.09%，未使用ROCK抑制剂的一只眼中内皮细胞密度下降至23.9%。

结论

围手术期使用ROCK抑制剂可能对角膜内皮有保护作用。