Qiu Yangyi, Ma Cong
State Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong Kong Special Administrative Region.
Data Brief. 2020 Feb 21;29:105313. doi: 10.1016/j.dib.2020.105313. eCollection 2020 Apr.
Bacterial transcription is a valid but underutilized target for antimicrobial agent discovery [1]. Nusbiarylins are the first-in-class bacterial ribosomal RNA synthesis inhibitors that possess potent activity against various types of multidrug-resistant bacteria with a novel mode of action by targeting the interaction of bacterial transcription factors NusB and NusE [2]. To facilitate the characterization of nusbiarylin derivatives produced by other researchers, high-performance liquid chromatography (HPLC) profiles, quantitative nuclear magnetic resonance (qNMR) and high-resolution mass spectrometry (HRMS) spectroscopic data were presented for the quick determination of purity and characterization of 95 nusbiarylin compounds. The data presented in this article supplement the H and C NMR data provided previously [3,4], and assist the reproduction of nusbiarylins for chemical, biological and drug discovery research.
细菌转录是抗菌药物发现的一个有效但未得到充分利用的靶点[1]。Nusbiarylins是一类新型的细菌核糖体RNA合成抑制剂，通过靶向细菌转录因子NusB和NusE的相互作用，对各种类型的多重耐药细菌具有强大的活性，其作用方式新颖[2]。为便于其他研究人员对所产生的nusbiarylin衍生物进行表征，本文给出了高效液相色谱（HPLC）图谱、定量核磁共振（qNMR）和高分辨率质谱（HRMS）光谱数据，用于快速测定95种nusbiarylin化合物的纯度和进行表征。本文所呈现的数据补充了之前提供的氢谱和碳谱数据[3,4]，并有助于nusbiarylins在化学、生物学和药物发现研究中的重现。
