Pilger Daniel, von Sonnleithner Christoph, Bertelmann Eckart
Department of Ophthalmology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
BMJ Open Ophthalmol. 2020 Feb 10;5(1):e000337. doi: 10.1136/bmjophth-2019-000337. eCollection 2020.
Conjunctival defects can be repaired with several mucosal tissues. The simplicity of harvesting oral mucosa and its wide availability makes it the preferred graft tissue for all indications requiring mucosal grafting. Through analysing the postsurgical outcomes and rate of revisions, this study explores the suitability of oral mucosa grafts, depending on the initial diagnosis.
We reviewed all the files of patients with a history of oral mucosal graft surgery, performed at our clinic between 2012 and 2018, focusing on complications and revision rates.
In total, we analysed 173 oral mucosa grafts in 131 patients. The most common initial diagnosis was tumour resection, followed by surgical complications, postenucleation socket syndrome, trauma and ocular surface disorders. Complication and revision rates depended highly on the initial diagnosis. Revision rates were highest if the initial diagnosis included ocular surface disorders or chemical trauma.
Oral mucosa grafting (OMG) is the most effective treatment for a wide range of ocular conditions involving conjunctival defects. Conjunctival defects that result from trauma or cicatricial surface diseases seem less suitable for OMG and may benefit from alternative graft tissue or treatment options.
结膜缺损可用多种黏膜组织修复。采集口腔黏膜操作简单且来源广泛，这使其成为所有需要黏膜移植适应症的首选移植组织。通过分析手术结果和翻修率，本研究探讨了根据初始诊断口腔黏膜移植的适用性。
我们回顾了2012年至2018年在我们诊所进行口腔黏膜移植手术患者的所有病历，重点关注并发症和翻修率。
我们总共分析了131例患者的173次口腔黏膜移植。最常见的初始诊断是肿瘤切除，其次是手术并发症、眼球摘除后眼窝综合征、创伤和眼表疾病。并发症和翻修率高度取决于初始诊断。如果初始诊断包括眼表疾病或化学创伤，翻修率最高。
口腔黏膜移植（OMG）是治疗多种涉及结膜缺损眼部疾病的最有效方法。由创伤或瘢痕性表面疾病导致的结膜缺损似乎不太适合OMG，可能受益于替代移植组织或治疗选择。
