US Army Institute of Surgical Research, JBSA Fort Sam Houston, Texas, USA.
Department of Emergency Health Sciences, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
Transfusion. 2020 May;60(5):1104-1107. doi: 10.1111/trf.15740. Epub 2020 Mar 10.
Prehospital hemorrhagic shock accounts for approximately 25,000 civilian deaths annually in the United States. A balanced, blood-based resuscitation strategy is hypothesized to be the optimal treatment for these patients. Due to logistical constraints, delivering a balanced, blood-based resuscitation is difficult in the prehospital setting. A low titer O whole blood (LTO WB) ground ambulance initiative, may help alleviate this capability gap.
A 37-year-old female was involved in a motor vehicle collision at approximately 16:30. While she was trapped inside the vehicle, her mental status deteriorated. The patient was successfully extricated at 17:04 and found to be in cardiac arrest. The paramedics and firefighters quickly secured her airway and applied a mechanical CPR device. The first responder team obtained return of spontaneous circulation, but the patient's blood pressure was 43/27 mmHg. The paramedics transfused one unit of LTO WB. Twenty-one minutes after the initial LTO WB transfusion, the air ambulance team transfused a second unit of LTO WB. Upon hospital arrival, the transfusion was completed, and the patient's shock index improved to 1.0. The trauma team identified a grade 5 splenic injury with active extravasation. Interventional radiology performed an angiogram and successfully embolized the tertiary branches of the inferior splenic pole. She was extubated on postinjury Day one and discharged to her home neurologically intact on postinjury Day 12.
The prehospital availability of LTO WB may enhance the resuscitation of critically ill trauma patients.
在美国,每年约有 25000 名平民死于院前失血性休克。平衡的、基于血液的复苏策略被假设为这些患者的最佳治疗方法。由于后勤限制,在院前环境中提供平衡的、基于血液的复苏是困难的。低滴度 O 型全血(LTO WB)地面救护计划可能有助于缓解这一能力差距。
一名 37 岁女性于大约 16:30 卷入一起机动车碰撞事故。当她被困在车内时,她的神志恶化。患者于 17:04 成功被救出,并被发现处于心脏骤停状态。护理人员和消防员迅速固定她的气道并应用机械心肺复苏设备。第一反应人员恢复了自主循环,但患者的血压为 43/27mmHg。护理人员输注了 1 单位 LTO WB。在初始 LTO WB 输注后 21 分钟,空中救护团队输注了第二单位 LTO WB。到达医院后,完成了输血,患者的休克指数改善至 1.0。创伤团队发现了 5 级脾损伤并伴有活跃的外渗。介入放射科进行了血管造影,并成功栓塞了脾下极的三级分支。她在损伤后第 1 天拔管,在损伤后第 12 天神经功能完整出院回家。
院前 LTO WB 的可用性可能会增强危重症创伤患者的复苏效果。