Biorefining Research Institute, Lakehead University, Thunder Bay, Ontario, Canada.
School of Sciences, Sandip University, Nashik, India.
Expert Opin Drug Discov. 2020 May;15(5):575-601. doi: 10.1080/17460441.2020.1730325. Epub 2020 Mar 10.
: To date, over 1,000 lichen secondary metabolites have been identified. Despite their promising cytotoxic properties, the number of literature reports on anticancer evaluation of lichenochemicals is limited. As cancer prevalence among the human population increases, there is growing interest in lichens as a natural source of secondary metabolites for anti-cancer drug discovery and development.: The lack of significant progress in lichen anticancer research is due to the low levels of cytotoxic compounds contained in lichens, the technical difficulties associated with their isolation and characterization, and the insufficient understanding of their mechanism of action on different cancer cell lines. In this review, the authors discuss these challenges and provide systematically organized information on the limitations and advantages of commonly used and newly developed methods for lichen exploration and screening of lichen secondary metabolites for their anticancer potential.: Recent research activities have demonstrated that lichen secondary metabolites possess chemotherapeutic properties. A systematic and multidisciplinary approach is required to advance lichen research and improve our understanding of the mechanisms responsible for the potent cytotoxic properties of lichenochemicals. More efforts need to focus on screening and discovery of new lichen-derived compounds with unique anticancer properties.
迄今为止，已经鉴定出超过 1000 种地衣次生代谢物。尽管它们具有有前途的细胞毒性特性，但关于地衣化学物质抗癌评估的文献报道数量有限。随着人类癌症发病率的增加，人们对地衣作为抗癌药物发现和开发的天然次生代谢物来源越来越感兴趣。
地衣抗癌研究缺乏显著进展，原因是地衣中所含的细胞毒性化合物水平低、其分离和表征的技术难度大，以及对地衣对不同癌细胞系作用机制的了解不足。在这篇综述中，作者讨论了这些挑战，并提供了关于常用和新开发的地衣探索方法以及对地衣次生代谢物抗癌潜力进行筛选的局限性和优点的系统组织信息。
最近的研究活动表明，地衣次生代谢物具有化疗特性。需要采用系统和多学科的方法来推进地衣研究，提高我们对地衣化学物质强大细胞毒性特性的机制的理解。需要更加关注筛选和发现具有独特抗癌特性的新的地衣衍生化合物。
