高钠和低钠摄入时血管紧张素受体阻滞剂坎地沙坦对大鼠脑血管自动调节功能的影响。
No effect of the angiotensin receptor blocker candesartan on cerebrovascular autoregulation in rats during very high and low sodium intake.
机构信息
Department of Nephrology, Copenhagen University Hospital at Herlev, Denmark.
Neurobiology Research Unit, Copenhagen University Hospital, Rigshospitalet, Denmark.
出版信息
J Renin Angiotensin Aldosterone Syst. 2019 Jul-Sep;20(3):1470320319874615. doi: 10.1177/1470320319874615.
Autoregulation of cerebral blood flow (CBF) denotes that CBF is constant despite fluctuation of blood pressure within wide limits. Inhibition of the renin-angiotensin system (RAS) is known to decrease the lower and upper limits of CBF autoregulation. We have previously shown that this includes inhibition by the angiotensin receptor blocker (ARB) candesartan. In the present study we investigated the influence of the ARB candesartan on the lower limit of CBF autoregulation in two groups of Sprague-Dawley rats, on high (4.0% Na) and low (0.004% Na) sodium diet, respectively. Control animals were given the same diet, but no ARB. CBF was studied with the laser Doppler method. Blood pressure was lowered by controlled bleeding. Results revealed that both high and low sodium diet with low and high renin levels respectively block the influence of candesartan on CBF autoregulation. This was expected in rats on a high salt diet with a low renin level, but unexpected in rats with a low salt intake with a high renin level.
脑血流自动调节是指尽管血压在较宽的范围内波动，脑血流量仍保持恒定。众所周知，肾素-血管紧张素系统（RAS）的抑制会降低脑血流量自动调节的下限和上限。我们之前已经表明，这包括血管紧张素受体阻滞剂（ARB）坎地沙坦的抑制作用。在本研究中，我们分别在高钠（4.0% Na）和低钠（0.004% Na）饮食的两组 Sprague-Dawley 大鼠中研究了 ARB 坎地沙坦对脑血流量自动调节下限的影响。对照组给予相同的饮食，但不给予 ARB。使用激光多普勒法研究脑血流量。通过控制放血降低血压。结果表明，高盐和低盐饮食分别伴有低和高肾素水平，均可阻断坎地沙坦对脑血流量自动调节的影响。这在低肾素水平高盐饮食的大鼠中是可以预期的，但在高盐饮食高肾素水平的大鼠中是出乎意料的。
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