法国婴儿癌症：发病率和生存率（2000-2014 年）。

Infant cancers in France: Incidence and survival (2000-2014).

机构信息

Registre National des cancers de l'Enfant, Registre National des Tumeurs Solides de l'Enfant, CHRU Nancy, Vandoeuvre-lès-Nancy, F-54500, France; Centre de Recherche en Epidémiologie et en Statistique Sorbonne-Paris Cité (CRESS), UMR 1153, INSERM, Université Paris, 75014, Paris, France.

Centre de Recherche en Epidémiologie et en Statistique Sorbonne-Paris Cité (CRESS), UMR 1153, INSERM, Université Paris, 75014, Paris, France; Registre National des cancers de l'Enfant, Registre National des hémopathies malignes de l'Enfant, AP-HP, Hôpital Paul Brousse, GHU Paris-Sud, Villejuif, F-94000, France.

出版信息

Cancer Epidemiol. 2020 Apr;65:101697. doi: 10.1016/j.canep.2020.101697. Epub 2020 Mar 7.

DOI:10.1016/j.canep.2020.101697

PMID:32155583

Abstract

BACKGROUND

On average 185 children are diagnosed each year in France with a cancer in their first year of life, representing 11 % of cancers diagnosed in children less than 15 years.

METHODS

A retrospective population-based observational study was conducted between 2000 and 2014 of all infants with a diagnosis of cancer using the National Registry of Childhood Cancers Database.

RESULTS

Out of 2760 cases of primary cancers in infancy, there were mainly neuroblastomas 30.1 %), central nervous system (CNS) tumors (16.1 %), leukemias (15.3 %), retinoblastomas (11.6 %), and Wilms tumors (6.9 %). Embryonal malignancies accounted for 55.2 % of cases. Most diagnoses showed a male excess, particularly for malignant gonadal germ-cell tumors (GCT) with a 17.5 sex-ratio. The annual incidence rate, 242.9 per million infants overall, was stable over the study period for all types of cancer. Most deaths occurred within the first month of life (70.8 % of deaths). The 5-year overall survival (5-y OS) was 81.0 % (95 %CI, 79.4-82.4) with large contrasts between diagnoses. The best 5-y OS (>85 %) were observed for retinoblastomas, carcinomas, nephroblastomas, GCT, neuroblastomas, and hepatoblastomas. Conversely, the lowest 5-y OS (<65 %) were observed for acute myeloid leukemias, CNS tumors, and lymphoid leukemias. We observed no substantial change over time (80.5 % [95 %CI, 77.7-82.9] in 2000-2004 and 82.6 % [95 %CI, 80.0-84.9] in 2010-2014) for all cancers combined. The same result has been found whatever the diagnostic group.

CONCLUSION

Our results contribute to better understand these tumors by quantifying their impact on the French population and assessing the burden of some devastating infant cancers.

摘要

背景

法国每年平均有 185 名婴儿在其生命的第一年被诊断患有癌症，占 15 岁以下儿童癌症诊断的 11%。

方法

采用全国儿童癌症登记数据库，对 2000 年至 2014 年所有确诊患有癌症的婴儿进行回顾性基于人群的观察性研究。

结果

在 2760 例原发性婴儿癌症中，主要为神经母细胞瘤（30.1%）、中枢神经系统（CNS）肿瘤（16.1%）、白血病（15.3%）、视网膜母细胞瘤（11.6%）和肾母细胞瘤（6.9%）。胚胎性恶性肿瘤占病例的 55.2%。大多数诊断结果显示男性居多，特别是恶性生殖细胞肿瘤（GCT）的性别比例为 17.5。所有类型癌症的年发病率为每百万婴儿 242.9 例，在整个研究期间保持稳定。大多数死亡发生在生命的第一个月内（70.8%的死亡）。5 年总生存率（5-y OS）为 81.0%（95%CI，79.4-82.4），不同诊断结果之间存在较大差异。5-y OS 最好的（>85%）为视网膜母细胞瘤、癌、肾母细胞瘤、GCT、神经母细胞瘤和肝母细胞瘤。相反，急性髓细胞白血病、CNS 肿瘤和淋巴白血病的 5-y OS 最低（<65%）。我们观察到在所有癌症中，随着时间的推移没有实质性变化（2000-2004 年为 80.5%[95%CI，77.7-82.9]，2010-2014 年为 82.6%[95%CI，80.0-84.9]）。无论诊断组如何，都得到了相同的结果。