Liu Guangmang, Mo Weiwei, Cao Wei, Jia Gang, Zhao Hua, Chen Xiaoling, Wu Caimei, Zhang Ruinan, Wang Jing
Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu, China.
Key Laboratory of Animal Disease-Resistance Nutrition, Ministry of Education, Chengdu, China.
J Food Biochem. 2020 May;44(5):e13167. doi: 10.1111/jfbc.13167. Epub 2020 Mar 10.
This study evaluated the effects of spermine supplementation on the digestion, transport, and metabolism of nutrients in the jejuna of piglets. Of the 80 piglets examined, 40 received 0.4 mmol/kg body weight spermine, and the other half were randomly distributed such that the restricted nutrient intake supplemented with the saline solution for 7 hr and 3, 6, or 9 days in pairs. Spermine supplementation increased the lipase and trypsin activities (p < .05), and spermine increased the mRNA levels of maltase, sucrase, and aminopeptidase N (APN) but decreased the lactase gene expression (p < .05). Moreover, spermine increased the mRNA expression levels of amino acid transporters (p < .05). Spermine increased the jejunum glycerolphosphocholine, lipid, and taurine levels and decreased the choline and amino acids levels (p < .05). In summary, spermine can promote the digestion, transport, and metabolism of nutrients in piglets. PRACTICAL APPLICATIONS: Meat, fish, dairy products, and fruits contain polyamines (i.e., spermine, spermidine, and putrescine). Spermine plays an important role in the cell proliferation, growth, and differentiation, and spermine supplementation can improve the growth of broilers, growth performance of early weaning piglets, and intestinal maturation. The results of this study suggest that spermine can improve the digestion, transport, and metabolism of nutrients in piglets.
本研究评估了补充精胺对仔猪空肠营养物质消化、转运和代谢的影响。在检查的80头仔猪中，40头接受0.4 mmol/kg体重的精胺，另一半随机分组，使限饲仔猪成对补充生理盐水7小时以及3、6或9天。补充精胺可提高脂肪酶和胰蛋白酶活性（p<0.05），精胺可提高麦芽糖酶、蔗糖酶和氨肽酶N（APN）的mRNA水平，但降低乳糖酶基因表达（p<0.05）。此外，精胺可提高氨基酸转运体的mRNA表达水平（p<0.05）。精胺可提高空肠甘油磷酸胆碱、脂质和牛磺酸水平，并降低胆碱和氨基酸水平（p<0.05）。总之，精胺可促进仔猪营养物质的消化、转运和代谢。实际应用：肉类、鱼类、乳制品和水果中含有多胺（即精胺、亚精胺和腐胺）。精胺在细胞增殖、生长和分化中起重要作用，补充精胺可改善肉鸡生长、早期断奶仔猪的生长性能和肠道成熟。本研究结果表明，精胺可改善仔猪营养物质的消化、转运和代谢。
