Guo Ying, Li Dongxue, Li Jiapei, Yang Nan, Wang Deyun
Department of Neurology, Pu'er People's Hospital, Pu'er, China.
Department of Internal Medicine, Pu'er City Prison Hospital, Pu'er, China.
J Korean Neurosurg Soc. 2020 Jul;63(4):463-469. doi: 10.3340/jkns.2019.0179. Epub 2020 Mar 11.
This study aimed to investigate the changes and significance of microRNA155 levels in serum of patients with cerebral small vessel disease (CSVD).
Thirty patients with CSVD who met the inclusion criteria were selected and divided into eight patients with lacunar infarction (LI) group and 22 patients with multiple lacunar infarction (MLI) combined with white matter lesions (WML) group according to the results of head magnetic resonance imaging (MRI). Thirty samples from healthy volunteers without abnormalities after head MRI examination were selected as the control group. The levels of serum microRNA155 in each group were determined by real-time polymerase chain reaction, and the correlation between microRNA155 in the serum of patients with CSVD and the increase of imaging lesions was analyzed by Spearman correlation analysis.
Compared with the control group, the serum microRNA155 level in the LI group, MLI combined with WML group increased, the difference was statistically significant (p<0.05); serum microRNA155 level was positively correlated with the increase of imaging lesions (p<0.05).
The change of serum microRNA155 level in patients with CSVD may be one of its self-protection mechanisms, and the intensity of this self-protection mechanism is positively correlated with the number of CSVD lesions.
本研究旨在探讨脑小血管病（CSVD）患者血清中微小RNA155水平的变化及意义。
选取30例符合纳入标准的CSVD患者，根据头部磁共振成像（MRI）结果分为8例腔隙性脑梗死（LI）组和22例多发腔隙性脑梗死（MLI）合并脑白质病变（WML）组。选取30例头部MRI检查无异常的健康志愿者样本作为对照组。采用实时聚合酶链反应测定各组血清微小RNA155水平，并通过Spearman相关分析探讨CSVD患者血清微小RNA155与影像学病变增加之间的相关性。
与对照组相比，LI组、MLI合并WML组血清微小RNA155水平升高，差异有统计学意义（p<0.05）；血清微小RNA155水平与影像学病变增加呈正相关（p<0.05）。
CSVD患者血清微小RNA155水平的变化可能是其自我保护机制之一，且这种自我保护机制的强度与CSVD病变数量呈正相关。
