Department of Anatomy, School of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran.
Life Sci. 2020 May 15;249:117534. doi: 10.1016/j.lfs.2020.117534. Epub 2020 Mar 7.
Tumors are dynamic tissue masses, so requiring continuous exposure to the host cells, nurturing them into pave a path for tumor growth and metastasis. C-X-C chemokine ligand 12 (CXCL12)/C-X-C chemokine receptor type 4 (CXCR4) is the key signaling for such aim. Gathering knowledge about the activity within this axis would deepen our insight into the utmost importance this signaling taken to attract and cross-connect multiple cells within the tumor microenvironment (TME) aiming for tumor progression and metastasis. The concept behind this review is to underscore the multi-tasking roles taken by CXCL12/CXCR4 signaling in tumor metastasis, and to also suggest some strategies to target the activities within this axis.
肿瘤是动态的组织肿块，因此需要持续暴露于宿主细胞中，滋养它们，为肿瘤生长和转移铺平道路。C-X-C 趋化因子配体 12（CXCL12）/C-X-C 趋化因子受体 4（CXCR4）是实现这一目标的关键信号。了解该轴中的活性将加深我们对这种信号在吸引和连接肿瘤微环境（TME）中的多种细胞以促进肿瘤进展和转移方面的重要性的认识。这篇综述的概念是强调 CXCL12/CXCR4 信号在肿瘤转移中所扮演的多任务角色，并提出一些针对该轴中活性的靶向策略。
