Su Yongcheng, Bai Qingquan, Zhang Wenqing, Xu Beibei, Hu Tianhui
Xiamen Key Laboratory for Tumor Metastasis, Cancer Research Center, School of Medicine, Xiamen University, Xiamen 361102, China.
Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
Biomolecules. 2025 Mar 20;15(3):454. doi: 10.3390/biom15030454.
Triple-negative breast cancer (TNBC) is a highly heterogeneous and aggressive subtype of breast cancer that faces therapeutic challenges due to a shortage of effective targeted therapies. The complex biology of TNBC renders its clinical management fraught with difficulties, especially regarding the immune microenvironment of the tumor. In recent years, long non-coding RNAs (lncRNAs) have been recognized as important gene regulators with key roles in tumor development and microenvironmental regulation. Previous studies have shown that lncRNAs play important roles in the immune microenvironment of TNBC, including the regulation of tumor immune escape and the function of tumor-infiltrating immune cells. However, despite the increasing research on lncRNAs, there are still many unanswered questions, such as their specific mechanism of action and how to effectively utilize them as therapeutic targets. Therefore, the aim of this study was to review the mechanisms of lncRNAs in the TNBC immune microenvironment, explore their regulatory roles in tumor immune escape and immune cell infiltration, and explore their prospects as potential therapeutic targets. By integrating the latest research results, this study aims to provide new ideas and directions for future TNBC treatment.
三阴性乳腺癌（TNBC）是一种高度异质性且侵袭性强的乳腺癌亚型，由于缺乏有效的靶向治疗方法，面临着治疗挑战。TNBC复杂的生物学特性使其临床管理充满困难，尤其是在肿瘤免疫微环境方面。近年来，长链非编码RNA（lncRNAs）已被公认为在肿瘤发生发展和微环境调节中起关键作用的重要基因调控因子。先前的研究表明，lncRNAs在TNBC的免疫微环境中发挥重要作用，包括调节肿瘤免疫逃逸和肿瘤浸润免疫细胞的功能。然而，尽管对lncRNAs的研究不断增加，但仍有许多问题未得到解答，例如它们的具体作用机制以及如何有效地将它们用作治疗靶点。因此，本研究的目的是综述lncRNAs在TNBC免疫微环境中的作用机制，探讨它们在肿瘤免疫逃逸和免疫细胞浸润中的调控作用，并探索它们作为潜在治疗靶点的前景。通过整合最新研究成果，本研究旨在为未来TNBC的治疗提供新的思路和方向。
