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[1例阑尾黏液腺癌腹膜转移经多学科治疗成功治愈]

[A Case of Peritoneal Metastasis of Appendiceal Mucinous Carcinoma Successfully Managed by Multidisciplinary Treatment].

作者信息

Yamamoto Eisuke, Muta Yuu, Itou Testuya, Chikatani Kenichi, Yamamoto Azusa, Muramatsu Shunsuke, Toyomasu Yoshitaka, Hatano Satoshi, Suzuki Okihide, Amano Kunihiko, Ishiguro Toru, Kumagai Youichi, Ishibashi Keiichiro, Mochiki Erito, Ishida Hideyuki

机构信息

Dept. of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University.

出版信息

Gan To Kagaku Ryoho. 2019 Dec;46(13):2125-2127.

Abstract

There is no established treatment for appendiceal mucinous adenocarcinoma. When this condition is complicated by pseudomyxoma peritonei(PMP), multidisciplinary treatment is often administered. A 40-year-old woman was diagnosed with right ovarian cancer for which laparotomy was performed. At the time of laparotomy, we considered the tumor to be an appendiceal carcinoma infiltrating the right ovary and performed ileocecal resection with lymph node dissection(D3)and right salpingo-oophorectomy. The pathological diagnosis was stage pT3, pN0, pM0, pStage Ⅱ mucinous adenocarcinoma of the appendix. Fourteen months later, the patient underwent abdominal total hysterectomy and left salpingo-oophorectomy because a CT scan suggested recurrence in the uterus, left fallopian tube, and ovary. Seventeen months after the second operation, despite adjuvant chemotherapy, CT revealed a peritoneal nodule in the pelvic cavity. Therefore, we administered chemotherapy comprising 5 lines for 32 months, which resulted in failure. CT showed an enlarged tumor and ascites and the patient became terminally ill. We repeatedly performed cytoreduction surgery and intraperitoneal chemotherapy, which improved her QOL. One year after discharge, abdominal CT showing an abdominal wall and intraperitoneal mass. We performed again cytoreduction surgery and intraperitoneal chemotherapy. Her postoperative course is good and she is currently an outpatient.

摘要

阑尾黏液腺癌尚无既定的治疗方法。当这种情况并发腹膜假黏液瘤(PMP)时,通常采用多学科治疗。一名40岁女性被诊断为右卵巢癌并接受了剖腹手术。在剖腹手术时,我们认为肿瘤是浸润右卵巢的阑尾癌,并进行了回盲部切除加淋巴结清扫(D3)和右输卵管卵巢切除术。病理诊断为pT3、pN0、pM0、pⅡ期阑尾黏液腺癌。14个月后,由于CT扫描提示子宫、左输卵管和卵巢复发,患者接受了腹式全子宫切除术和左输卵管卵巢切除术。第二次手术后17个月,尽管进行了辅助化疗,CT仍显示盆腔有一个腹膜结节。因此,我们给予了5线化疗共32个月,但治疗失败。CT显示肿瘤增大并有腹水,患者病情危重。我们反复进行减瘤手术和腹腔内化疗,改善了她的生活质量。出院一年后,腹部CT显示腹壁和腹腔内有肿块。我们再次进行了减瘤手术和腹腔内化疗。她术后恢复良好,目前是门诊患者。

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