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[腹腔镜下胃局部切除术治疗去分化型胃脂肪肉瘤 1 例]

[A Case of Laparoscopic Gastric Local Resection for Dedifferentiated Gastric Liposarcoma].

作者信息

Toshiyama Reishi, Hoshino Hiromitsu, Kimura Toshihiro, Murakami Masakazu, Koma Yuichiro, Watanabe Shin, Tanigawa Takahiko

机构信息

Dept. of Surgery, Kawasaki Hospital.

出版信息

Gan To Kagaku Ryoho. 2019 Dec;46(13):2204-2206.

PMID:32156879
Abstract

A 73 year-old-woman visited our emergency department with a sudden stomach ache. A 7 cm tumor was found on the greater curvature side of the stomach by contrast-enhanced CT, and showed mosaic pattern when visualized with a contrast agent. An esophagogastroduodenoscopy showed normal mucosal gastric surface with compression findings by the gastric submucosal tumor, and therefore she was admitted to our department for surgery. Abdominal ultrasound revealed an uneven gastric submucosal tumor containing cystic components with a clear border, and gastric GIST was suspected due to its appearance, and therefore, laparoscopic gastric local resection was performed. The gastric tumor was located on the dorsal side of the greater curvature and adhered highly to the retroperitoneum and spleen. The omental incision was conducted first, and the adhesion around the tumor was carefully detached, following which wedge resection was performed using Endo-GIA®at the base of the tumor. The pathological findings of the resected specimens were mainly spindle-shaped tumor cells rich in polymorphism with a high degree of necrosis, and did not seem to be conclusively GIST; as such, various immunological tests were performed.c -kit(-), DOG-1(-), S-100 p(-), desmin(-), a-SMA(focal+), p16(+), MDM2(+), CDK4(+) results led to the diagnosis of dedifferentiated liposarcoma. The patient is currently being followed up with and is alive without recurrence 10 months after the operation.

摘要

一名73岁女性因突发胃痛前来我院急诊科就诊。增强CT检查发现胃大弯侧有一个7厘米的肿瘤,注入造影剂后呈马赛克样表现。食管胃十二指肠镜检查显示胃黏膜表面正常,但有胃黏膜下肿瘤造成的压迫表现,因此她被收入我科准备手术。腹部超声显示一个不均匀的胃黏膜下肿瘤,含有囊性成分,边界清晰,因其表现怀疑为胃胃肠道间质瘤(GIST),遂行腹腔镜胃局部切除术。胃肿瘤位于大弯背侧,与腹膜后和脾脏高度粘连。首先进行网膜切开,小心分离肿瘤周围的粘连,然后在肿瘤基底部使用Endo-GIA®进行楔形切除。切除标本的病理检查结果主要为多形性丰富的梭形肿瘤细胞,伴有高度坏死,似乎不能确诊为GIST;因此,进行了各种免疫检测。c-kit(-)、DOG-1(-)、S-100 p(-)、结蛋白(-)、α-平滑肌肌动蛋白(局灶性阳性)、p16(+)、MDM2(+)、细胞周期蛋白依赖性激酶4(+)的结果导致诊断为去分化脂肪肉瘤。患者目前正在接受随访,术后10个月仍存活且无复发。

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引用本文的文献

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Laparoscopic management of a gastric liposarcoma with malignant transformation from a gastric lipoma: A rare case report.腹腔镜治疗胃脂肪瘤恶变的胃脂肪肉瘤:1例罕见病例报告
Int J Surg Case Rep. 2023 Dec;113:109039. doi: 10.1016/j.ijscr.2023.109039. Epub 2023 Nov 21.