[山口县结直肠癌辅助化疗问卷调查]

[Questionnaire Survey on Adjuvant Chemotherapy for Colorectal Cancer in Yamaguchi Prefecture].

作者信息

Yoshida Shin, Suzuki Nobuaki, Takahashi Tsuyoshi, Sakamoto Kazuhiko, Tokuno Kazuhisa, Harada Eijiro, Hamano Kimikazu, Nakamura Masato, Nagano Hiroaki

机构信息

Dept. of Gastroenterological, Breast and Endocrine Surgery, Yamaguchi University Graduate School of Medicine.

出版信息

Gan To Kagaku Ryoho. 2019 Dec;46(13):2446-2448.

PMID:32156960

Abstract

A questionnaire survey on postoperative chemotherapy for colorectal cancer was conducted in 22 hospitals in Yamaguchi Prefecture. Adjuvant chemotherapy was performed in<95% of Stage Ⅲ cancer, and oxaliplatin(OX)combination therapy was selected depending on the risk of recurrence. However, the proportion of OX combination therapy was lower than that in other prefectures, which was 24% in Stage Ⅲa, 44% in Ⅲb, and 76% in Ⅲc. In addition, among the OX combination therapy regimens(FOLFOX or CAPOX), the proportion of FOLFOX administration was higher in Yamaguchi Prefecture than in other prefectures. In Stage Ⅱ, most hospitals set up high-risk factors for recurrence and underwent adjuvant chemotherapy. FU-based monotherapy was selected in 80% of hospitals. A few hospitals decided the requirement of OX combination therapy based on age alone. In Yamaguchi Prefecture, the indication of postoperative adjuvant chemotherapy for colorectal cancer was almost standard; however, the rate of administering OX combination therapy was low.

摘要

对山口县22家医院进行了一项关于结直肠癌术后化疗的问卷调查。Ⅲ期癌症患者中<95%接受了辅助化疗，并根据复发风险选择了奥沙利铂（OX）联合治疗。然而，OX联合治疗的比例低于其他县，Ⅲa期为24%，Ⅲb期为44%，Ⅲc期为76%。此外，在OX联合治疗方案（FOLFOX或CAPOX）中，山口县FOLFOX给药的比例高于其他县。在Ⅱ期，大多数医院设定了复发的高危因素并进行了辅助化疗。80%的医院选择了基于氟尿嘧啶（FU）的单一疗法。少数医院仅根据年龄决定是否需要OX联合治疗。在山口县，结直肠癌术后辅助化疗的指征几乎是标准的；然而，OX联合治疗的给药率较低。