Awerbuch G, Oommen K J, Sandyk R
Department of Neurology, Arizona Health Sciences Center, Tucson 85724.
Int J Neurosci. 1988 Nov;43(1-2):115-22. doi: 10.3109/00207458808985788.
In a previous study of epileptic phenomena in 19 patients with partial complex seizures, it was noted that seizures of left temporal lobe origin had a higher incidence of secondary generalization. To evaluate this observation further, we retrospectively reviewed reports of EEGs for evidence of focal interictal epileptiform discharges (FIED) of temporal lobe origin and correlated this finding with seizure type. Of 3,276 EEG reports reviewed, 195 showed FIED. The medical records of these patients were reviewed and 79 had sufficient information therein to enable seizure classification. Of 79 patients, 61 had secondary generalized seizures, 45 with left temporal FIED, 16 with right FIED. Of 79 patients, 18 had partial seizures, 13 with right temporal FIED, 5 with left FIED (p less than 0.001). These findings suggest that seizures of left temporal lobe origin may have a higher incidence of secondary generalization. The significance of this observation and its relevance to medical and surgical treatment of complex partial seizures is discussed.
在之前一项针对19例部分性癫痫发作患者癫痫现象的研究中，注意到起源于左侧颞叶的癫痫发作继发全身性发作的发生率更高。为了进一步评估这一观察结果，我们回顾性分析了脑电图报告，以寻找颞叶起源的局灶性发作间期癫痫样放电（FIED）证据，并将这一发现与癫痫发作类型相关联。在3276份回顾的脑电图报告中，195份显示有FIED。对这些患者的病历进行了审查，其中79份有足够信息进行癫痫发作分类。在79例患者中，61例有继发全身性发作，45例左侧颞叶有FIED，16例右侧颞叶有FIED。在79例患者中，18例有部分性发作，13例右侧颞叶有FIED，5例左侧颞叶有FIED（p小于0.001）。这些发现表明，起源于左侧颞叶的癫痫发作继发全身性发作的发生率可能更高。本文讨论了这一观察结果的意义及其与复杂部分性癫痫发作的药物和手术治疗的相关性。
