比较咪达唑仑和丁丙诺啡联合氯胺酮或右美托咪定在吼猴（Alouatta guariba clamitans）输精管结扎术中的化学保定效果。
Comparison of midazolam and butorphanol combined with ketamine or dexmedetomidine for chemical restraint in howler monkeys (Alouatta guariba clamitans) for vasectomy.
机构信息
Veterinary School, UFMG, Belo Horizonte, Brazil.
Faculty of Veterinary Medicine, UFRGS, Porto Alegre, Brazil.
出版信息
J Med Primatol. 2020 Aug;49(4):179-187. doi: 10.1111/jmp.12467. Epub 2020 Mar 10.
BACKGROUND
This study evaluated and compared cardiorespiratory and blood gas parameters, as well as sedation, analgesia and recovery of two protocols: ketamine (10 mg/kg) or dexmedetomidine (10 μg/kg), with midazolam (0.5 mg/kg) and butorphanol (0.3 mg/kg), IM (KBM and DBM, respectively) in brown howler monkeys (Alouatta guariba clamitans).
MATERIAL AND METHODS
Twelve brown howler monkeys were selected in two groups and evaluated for cardiorespiratory parameters and sedation, from 5-30 minutes after latency. Blood gas and arterial lactate were taken at 5 and 30 minutes. In the end, time and quality of recovery were evaluated.
RESULTS
The HR in DBM group was significantly lower at all times. The sedation score was higher in DBM. Recovery in DBM was faster. All animals had moderate hypoxaemia.
CONCLUSION
Both protocols produce satisfactory anaesthesia and analgesia, but DBM provides deeper sedation with faster recovery. Oxygen supplementation is recommended in both due to hypoxaemia.
背景
本研究评估并比较了两种方案（分别为氯胺酮[10mg/kg]和右美托咪定[10μg/kg]）与咪达唑仑[0.5mg/kg]和布托啡诺[0.3mg/kg]肌内注射（KBM 和 DBM）的心肺和血气参数以及镇静、镇痛和恢复情况，对象为褐吼猴（Alouatta guariba clamitans）。
材料与方法
选择了 12 只褐吼猴分为两组，在潜伏期后 5-30 分钟评估心肺参数和镇静情况。在 5 分钟和 30 分钟时采集血气和动脉血乳酸。最后，评估恢复的时间和质量。
结果
DBM 组的 HR 在所有时间均显著降低。DBM 组的镇静评分更高。DBM 的恢复更快。所有动物均有中度低氧血症。
结论
两种方案均能产生满意的麻醉和镇痛效果，但 DBM 提供更深的镇静作用和更快的恢复速度。由于低氧血症，建议两种方案都进行氧补充。
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