Fioranelli Massimo, Jafferany Mohammad, Wollina Uwe, Tirant Michael, Van Thuong Nguyen, Lotti Torello
Department of Nuclear Physics, Sub-Nuclear and Radiation, G. Marconi University, Rome, Italy.
Central Michigan University College of Medicine, Saginaw, Michigan, USA.
Dermatol Ther. 2020 May;33(3):e13300. doi: 10.1111/dth.13300. Epub 2020 Mar 22.
Melasma is an acquired circumscribed hyperpigmented disorder seen mainly on the malar area of face and other parts of body. We evaluated the safety and efficacy of two different creams for melasma. Sixty volunteers with melasma were evaluated in this study, divided in three groups: A, B, and C. Patients in groups A and B were treated with same creams with the exception of addition of Tranexamic acid in cream B. Patients in group C were treated with placebo cream containing petrolatum only, respectively, twice daily for 10 weeks. Melasma Areas and Severity Index (MASI) score, melanin index (MI) and adverse events were evaluated every 4 weeks. MASI scores declined significantly in groups A and B compared to group C (P < .05). Cream B, containing tranexamic acid, resulted superior to cream A in subjects with hypervascular melasma. No adverse reactions were observed in all groups. Both active creams are safe and effective for melasma and should be selected according to normal or hypervascular type of melasma. Cream B (containing tranexamic acid) should be prescribed instead of cream A (not containing tranexamic acid) to subjects with hypervascular melasma.
黄褐斑是一种后天性局限性色素沉着紊乱疾病，主要见于面部的颧部及身体的其他部位。我们评估了两种不同乳膏治疗黄褐斑的安全性和有效性。本研究纳入了60名黄褐斑志愿者，分为三组：A组、B组和C组。A组和B组患者使用相同的乳膏，只是B组乳膏中添加了氨甲环酸。C组患者使用仅含凡士林的安慰剂乳膏，均每日两次，持续治疗10周。每4周评估黄褐斑面积和严重程度指数（MASI）评分、黑色素指数（MI）及不良事件。与C组相比，A组和B组的MASI评分显著下降（P＜0.05）。对于伴有血管增生性黄褐斑的受试者，含氨甲环酸的B组乳膏效果优于A组乳膏。所有组均未观察到不良反应。两种活性乳膏治疗黄褐斑均安全有效，应根据黄褐斑是普通型还是血管增生型来选择。对于伴有血管增生性黄褐斑的受试者，应开具B组乳膏（含氨甲环酸）而非A组乳膏（不含氨甲环酸）。
