Department of Obstetrics and Gynecology, SARA Fetal MEG Research Center, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Department of Pediatrics, University of Arkansas for Medical Sciences, Arkansas Children's Research Institute, Little Rock, AR, USA.
Clin EEG Neurosci. 2020 Sep;51(5):331-338. doi: 10.1177/1550059420909658. Epub 2020 Mar 11.
Developmental origin of health and disease states that an adverse intrauterine environment can lead to different diseases in later life. In this study, we aimed to explore the effect of maternal pregestational diabetes on the fetal brain activity using magnetoencephalography (MEG). Forty participants were included in an observational study with 9 type 1 and 19 type 2 diabetic pregnant women compared with data from 12 nondiabetic participants. Spontaneous fetal MEG signals were recorded and power spectral density was computed in 4 standard frequency bands. Group differences were investigated using analysis of covariance. . Our results showed that type 1 group was significantly different ( < .05) from the reference group for 3 of the 4 brain activity frequency bands, while in type 2 group, 2 bands exhibited this trend. When dichotomized based on the maternal glycemic control, significant differences in all bands were observed between the poor-control and reference groups. . The fetal background brain activity parameters appear to be altered in diabetic pregnancy in comparison with the reference low-risk group. The study showed that maternal pregestational diabetes could potentially influence in utero neurodevelopment.
健康与疾病的发育起源表明，不良的宫内环境会导致以后生活中的不同疾病。在这项研究中，我们旨在使用脑磁图（MEG）来探讨母体孕前糖尿病对胎儿大脑活动的影响。
一项观察性研究纳入了 40 名参与者，其中包括 9 名 1 型糖尿病孕妇和 19 名 2 型糖尿病孕妇，并与 12 名非糖尿病孕妇的数据进行了比较。记录了自发的胎儿 MEG 信号，并在 4 个标准频带中计算了功率谱密度。使用协方差分析研究了组间差异。
我们的结果表明，1 型组在 4 个脑活动频带中的 3 个频带与参考组存在显著差异（<0.05），而 2 型组中有 2 个频带存在这种趋势。当根据母体血糖控制进行二分法时，在不良控制组与参考组之间，所有频带均存在显著差异。
与低风险参考组相比，糖尿病妊娠中胎儿背景脑活动参数似乎发生了改变。这项研究表明，母体孕前糖尿病可能会对宫内神经发育产生潜在影响。
