欧米伽-3脂肪酸对稳定和重塑动脉粥样硬化的益处。
The Benefits of Omega-3 Fats for Stabilizing and Remodeling Atherosclerosis.
作者信息
DiNicolantonio James J, O'Keefe James H
机构信息
James J. DiNicolantonio, PharmD, and James H. O'Keefe, MD, MSMA member since 2003, are at Saint Luke's Mid America Heart Institute, Kansas City, Missouri.
出版信息
Mo Med. 2020 Jan-Feb;117(1):65-69.
Abstract
The majority of acute coronary syndromes are caused by the rupture of plaques rendered vulnerable by oxidized lipids, inflammation, and a thin fibrous cap with reduced collagen and smooth muscle cell content.2 Thus, stabilizing and reversing vulnerable atherosclerotic plaques can help to prevent cardiovascular events. In this regard, long-chain omega-3 fatty acids have a plethora of data for stabilizing vulnerable atherosclerotic plaques as well as reversing atherosclerosis. This review paper will summarize the observational data as well as animal and human studies supporting such a role and further discuss the current controversies around omega-3 supplementation.
摘要
大多数急性冠状动脉综合征是由斑块破裂引起的，这些斑块因氧化脂质、炎症以及胶原和平滑肌细胞含量减少的薄纤维帽而变得易损。因此，稳定和逆转易损性动脉粥样硬化斑块有助于预防心血管事件。在这方面，有大量数据表明长链ω-3脂肪酸可稳定易损性动脉粥样硬化斑块并逆转动脉粥样硬化。本文将总结支持这一作用的观察数据以及动物和人体研究，并进一步讨论围绕ω-3补充剂的当前争议。
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Cardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceridemia.依泽替米贝降低严重高甘油三酯血症患者心血管风险
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