Kim Jung-Ho, Kim Beom Seok, Lee Sang-Kyou
Research Institute for Precision Immune-Medicine, Good T Cells, Inc., Seoul 03722, Korea.
Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul 03722, Korea.
Immune Netw. 2020 Feb 11;20(1):e4. doi: 10.4110/in.2020.20.e4. eCollection 2020 Feb.
Tregs have a role in immunological tolerance and immune homeostasis by suppressing immune reactions, and its therapeutic potential is critical in autoimmune diseases and cancers. There have been multiple studies conducted on Tregs because of their roles in immune suppression and therapeutic potential. In tumor immunity, Tregs can promote the development and progression of tumors by preventing effective anti-tumor immune responses in tumor-bearing hosts. High infiltration of Tregs into tumor tissue results in poor survival in various types of cancer patients. Identifying factors specifically expressed in Tregs that affect the maintenance of stability and function of Tregs is important for understanding cancer pathogenesis and identifying therapeutic targets. Thus, manipulation of Tregs is a promising anticancer strategy, but finding markers for Treg-specific depletion and controlling these cells require fine-tuning and further research. Here, we discuss the role of Tregs in cancer and the development of Treg-targeted therapies to promote cancer immunotherapy.
调节性T细胞（Tregs）通过抑制免疫反应在免疫耐受和免疫稳态中发挥作用，其治疗潜力在自身免疫性疾病和癌症中至关重要。由于Tregs在免疫抑制和治疗潜力方面的作用，已经进行了多项关于Tregs的研究。在肿瘤免疫中，Tregs可通过阻止荷瘤宿主中有效的抗肿瘤免疫反应来促进肿瘤的发生和发展。Tregs大量浸润肿瘤组织会导致各类癌症患者的生存率降低。识别Tregs中特异性表达的、影响Tregs稳定性和功能维持的因子，对于理解癌症发病机制和确定治疗靶点至关重要。因此，操纵Tregs是一种有前景的抗癌策略，但寻找Treg特异性清除的标志物并控制这些细胞需要进行微调并进一步研究。在此，我们讨论Tregs在癌症中的作用以及开发靶向Tregs的疗法以促进癌症免疫治疗。
