3型五聚体蛋白在曲霉病中的作用：现状与展望
The Role of Pentraxin 3 in Aspergillosis: Reality and Prospects.
作者信息
Kang Yuening, Yu Yuetian, Lu Liangjing
机构信息
Department of Rheumatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Department of Critical Care Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
出版信息
Mycobiology. 2020 Feb 8;48(1):1-8. doi: 10.1080/12298093.2020.1722576. eCollection 2020.
Abstract
Pentraxin 3 (PTX3) is a soluble pattern recognition receptor (PRR), which is produced by several kinds of cells, such as neutrophils, dendritic cells, macrophages, and epithelial cells. PTX3 is known to play an important protective effect against . Genetic linkage in gene-targeted mice and human PTX3 plays a non-redundant role in the immune protection against specific pathogens, especially . Recent studies have shown that the polymorphism of PTX3 is associated with increased susceptibility to invasive aspergillosis (IA). In this review, we provide an overview of these studies that underline the potential of PTX3 in diagnosis and therapy of IA.
摘要
五聚体蛋白3（PTX3）是一种可溶性模式识别受体（PRR），由多种细胞产生，如中性粒细胞、树突状细胞、巨噬细胞和上皮细胞。已知PTX3对……发挥重要的保护作用。基因靶向小鼠中的基因连锁以及人类PTX3在针对特定病原体的免疫保护中发挥非冗余作用，尤其是……。最近的研究表明，PTX3的多态性与侵袭性曲霉病（IA）易感性增加有关。在本综述中，我们概述了这些强调PTX3在IA诊断和治疗中的潜力的研究。
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