Deng Lin, Feng Dingqing, Liang Jing, Luo Jie, Ling Bin
China-Japan Friendship Hospital, Beijing, China.
Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.
Front Med (Lausanne). 2020 Feb 25;7:58. doi: 10.3389/fmed.2020.00058. eCollection 2020.
Microcystic stromal tumor is a recently described subtype of ovarian tumor characterized by microcystic pattern and diffuse immunoreactivity for CD10, vimentin, and β-catenin and negative for EMA. However, its diagnostic criterion and standard treatment remain unclear. We report a rare case of a left side microcystic stromal tumor with diameter about 7 cm in a 25-year-old female and summarize all cases of MCST reported in this study. The present patient underwent left ovarian tumor resection. Generally, the tumor was solid and cystic mixed. Immunohistochemically, the tumor was expressed CD10, WT1, cyclin D1 and vimentin, and nuclear immunoreactivity for β-catenin but negative for α-inhibin, calretinin, CK AE1/AE3, PLAP, SALL-4, CK7, P53, EMA, CD99, AFP, desmin, CgA, E-cadherin, and melanA. Unilateral ovary, solid-cystic, and a larger than 4-8 cm pelvic mass without serious abdominal pain are its clinical features. The immunophenotype of vimentin+/CD10+/WT-1+/β-catenin+(nuclei)/cyclin D1+ is supportive of diagnosis. For these patients, unilateral oophorectomy dissection could be selected.
微囊性间质瘤是一种最近描述的卵巢肿瘤亚型，其特征为微囊性结构，对CD10、波形蛋白和β-连环蛋白呈弥漫性免疫反应，而对上皮膜抗原（EMA）呈阴性。然而，其诊断标准和标准治疗方法仍不明确。我们报告了一例罕见的左侧微囊性间质瘤病例，患者为一名25岁女性，肿瘤直径约7厘米，并总结了本研究中报告的所有微囊性间质瘤病例。该患者接受了左侧卵巢肿瘤切除术。一般来说，肿瘤为实性和囊性混合。免疫组织化学检查显示，肿瘤表达CD10、WT1、细胞周期蛋白D1和波形蛋白，β-连环蛋白呈核免疫反应阳性，但α-抑制素、钙视网膜蛋白、细胞角蛋白AE1/AE3、胎盘碱性磷酸酶、SALL-4、细胞角蛋白7、P53、EMA、CD99、甲胎蛋白、结蛋白、嗜铬粒蛋白A、E-钙黏蛋白和黑色素A呈阴性。单侧卵巢、实性-囊性以及大于4 - 8厘米的盆腔肿块且无严重腹痛是其临床特征。波形蛋白+/CD10+/WT-1+/β-连环蛋白+（细胞核）/细胞周期蛋白D1+的免疫表型有助于诊断。对于这些患者，可以选择单侧卵巢切除术。
