PSPC1：肿瘤进展的一个背景决定因素。
PSPC1: a contextual determinant of tumor progression.
作者信息
Lang Yaw-Dong, Jou Yuh-Shan
机构信息
Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
出版信息
Mol Cell Oncol. 2020 Feb 3;7(2):1721253. doi: 10.1080/23723556.2020.1721253. eCollection 2020.
Abstract
Protein-tyrosine kinase 6 (PTK6) sequestrated by its substrate paraspeckle component 1 (PSPC1) in nucleus is a tumor suppressor. PSPC1 functions as a contextual determinant of oncogenic subcellular translocations to synergize PSPC1/β-catenin and PTK6 tumorigenesis. Besides, PSPC1 C-terminal interacting domain (PSPC1-CT131), a dual inhibitor of PSPC1 and PTK6, suppresses cancer progression.
摘要
在细胞核中被其底物副斑点成分1（PSPC1）隔离的蛋白酪氨酸激酶6（PTK6）是一种肿瘤抑制因子。PSPC1作为致癌亚细胞易位的背景决定因素，协同PSPC1/β-连环蛋白和PTK6的肿瘤发生。此外，PSPC1 C末端相互作用结构域（PSPC1-CT131）是PSPC1和PTK6的双重抑制剂，可抑制癌症进展。
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