Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics, School of Pharmacy, Tianjin Medical University, Tianjin 300070, P.R. China.
Institute of Materials and Environmental Chemistry, Hungarian Academy of Sciences, Department of Physics, Budapest University of Technology and Economics, Budafoki ut8, 1111 Budapest, Hungary.
Org Biomol Chem. 2020 Mar 25;18(12):2321-2325. doi: 10.1039/d0ob00341g.
The host-guest interaction of nitroxide radicals with water-soluble pillar[n]arenes was studied for the first time by electron paramagnetic resonance spectroscopy and NMR spectroscopy. Our results showed that this interaction strongly depended on the 4-substituents of nitroxides and the cavity size of pillar[n]arenes. The host-guest interaction with water-soluble pillar[6]arene WP6 effectively increased the thermodynamic and kinetic stability of nitroxide radical 4-AT toward ascorbic acid, thus expanding its potential biomedical applications.
首次通过电子顺磁共振波谱和 NMR 波谱研究了氮氧自由基与水溶性杯芳烃的主客体相互作用。我们的结果表明，这种相互作用强烈依赖于氮氧自由基的 4-取代基和杯芳烃的空腔大小。与水溶性杯[6]芳烃 WP6 的主客体相互作用有效地提高了氮氧自由基 4-AT 对抗坏血酸的热力学和动力学稳定性，从而扩大了其在生物医学中的潜在应用。
