Carvalho Davi Vilela, Santos Renata Maria Silva, Magalhães Helen Cardoso de, Souza Mariana Soares de, Christo Paulo Pereira, Almeida-Leite Camila Megale de, Scalzo Paula Luciana
Universidade Federal de Minas Gerais, Programa de Pós-Graduação em Neurociências, Belo Horizonte MG, Brazil.
Universidade Federal de Minas Gerais, Programa de Pós-Graduação em Patologia, Belo Horizonte MG, Brazil.
Arq Neuropsiquiatr. 2020 Feb;78(2):70-75. doi: 10.1590/0004-282X20190136.
Although fatigue is an expressive symptom of Parkinson's disease (PD), few studies have investigated the association between fatigue, mobility and walking capacity of these patients.
To investigate whether fatigue is an independent factor associated with mobility and the walking capacity in patients with PD.
Forty-eight patients with PD (22 with fatigue) were tested for mobility and their walking capacity: Timed Up and Go (TUG), 10-Meter Walk Test (10MWT) at usual and fastest speed, and 6-Minute Walk Test (6MWT). Fatigue was measured with Parkinson's Fatigue Scale (PFS-16). Linear regression analysis was used to investigate if fatigue is an independent factor contributing to variance in mobility and walking capacity.
There was a positive correlation between PFS-16 and TUG (rs=0.385; p=0.007). There was a negative correlation between PFS-16 and 10MWT at comfortable (r=-0.385; p=0.007) and fast speeds (r=-0.396; p=0.005), and 6MWT (r=-0.472; p=0.001). Linear regression analysis revealed that fatigue did not explain the variance of TUG and 10MWT. PFS-16, age and section III of UPDRS explained 49.6% (adjusted R2; p<0.001) variance in the 6MWT, and fatigue was the most significant predictor (F=-32.1; p=0.022).
Fatigue is an independent factor contributing to the distance covered during 6MWT in patients with PD. Our results highlight the importance of recognition and management of this symptom.
尽管疲劳是帕金森病（PD）的一个典型症状，但很少有研究调查这些患者的疲劳、活动能力和步行能力之间的关联。
研究疲劳是否是与PD患者的活动能力和步行能力相关的独立因素。
对48例PD患者（22例有疲劳症状）进行活动能力和步行能力测试：定时起立行走测试（TUG）、以正常速度和最快速度进行的10米步行测试（10MWT）以及6分钟步行测试（6MWT）。使用帕金森疲劳量表（PFS-16）测量疲劳程度。采用线性回归分析来研究疲劳是否是导致活动能力和步行能力差异的独立因素。
PFS-16与TUG之间存在正相关（rs = 0.385；p = 0.007）。PFS-16与舒适速度（r = -0.385；p = 0.007）和快速速度（r = -0.396；p = 0.005）下的10MWT以及6MWT之间存在负相关（r = -0.472；p = 0.001）。线性回归分析显示，疲劳并不能解释TUG和10MWT的差异。PFS-16、年龄和UPDRS第三部分解释了6MWT中49.6%（调整后R²；p < 0.001）的差异，且疲劳是最显著的预测因素（F = -32.1；p = 0.022）。
疲劳是导致PD患者6MWT步行距离的一个独立因素。我们的结果凸显了识别和处理这一症状的重要性。
